Epilepsy and multiple sclerosis in Sicily: A population-based study
Epilepsy and multiple sclerosis in Sicily: A population-based study
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DOI：
10.1046/j.1528-1157.2003.09203.x
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发表时间：
2003-01-01
期刊：
影响因子：
5.6
通讯作者：
Reggio, A
中科院分区：
文献类型：
--
作者：
Nicoletti, A;Sofia, V;Reggio, A
目的：为了评估癫痫和多发性硬化（MS）之间的关联，我们分析了癫痫的发病率在人口为基础的发病队列MS在卡塔尼亚，西西里。方法：根据Poser的诊断标准，170例MS事件已确定从1975年至1994年在卡塔尼亚市。所有这些受试者都接受了完整的神经系统检查，以确认MS的诊断，并确定那些有癫痫发作史的患者。癫痫的诊断依据国际抗癫痫联盟（ILAE）1993年提出的诊断标准，癫痫发作的分类依据ILAE 1981年的分类标准。结果：1975 ~ 1994年共收治MS患者170例。MS的平均年发病率为2.3/100，000（95% CI，2.0-2.6）。在170例定义的MS患者中，4例在发病后发生癫痫，也诊断为MS，癫痫的发生率为285/100，000人年（95% CI，119-684），根据世界标准人群调整年龄后为147.8/100，000。使用寿命表方法评估MS发作后发生癫痫的累积风险，1年时为0，5年时为1.76%。在这4例患者中，3例被归类为部分性癫痫发作与继发性全身性发作和强直阵挛性seizure.Conclusions：我们的数据是一致的，与文献报道的MS患者中发展癫痫的风险是三倍高于一般人群。
Purpose: To evaluate the association between epilepsy and multiple sclerosis (MS), we analyzed the incidence of epilepsy in a population-based incidence cohort of MS in Catania, Sicily.Methods: According to Poser's diagnostic criteria, 170 incident cases of MS have been identified from 1975 to 1994 in the city of Catania. All these subjects underwent a complete neurological examination to confirm the diagnosis of MS and to identify those patients with a history of seizures. Diagnosis of epilepsy was based on the criteria proposed by the International League Against Epilepsy (ILAE) in 1993, and seizures were classified according to the classification of the ILAE, 1981.Results: From 1975 to 1994, 170 subjects with MS had the clinical onset of the disease. The mean annual incidence of MS was 2.3/100,000 (95% CI, 2.0-2.6). Of the 170 defined MS patients, four developed epilepsy after the onset and also diagnosis of MS, giving an incidence rate of epilepsy of 285/100,000 person years at risk (95% CI, 119-684) and 147.8/100,000 when age adjusted to the world standard population. The cumulative risk of developing epilepsy after the onset of MS, evaluated by using the life-table methods, was zero at 1 year and 1.76% at 5 years. Of these four patients, three were classified as having partial seizures with secondary generalization and one with tonic-clonic seizures.Conclusions: Our data are consistent with those reported in literature suggesting that the risk of developing epilepsy is threefold higher among MS patients than in the general population.