EVOLUTION OF THE DROSOPHILA-MELANOGASTER-SIGMA VIRUS SYSTEM IN A NATURAL-POPULATION FROM TUBINGEN
EVOLUTION OF THE DROSOPHILA-MELANOGASTER-SIGMA VIRUS SYSTEM IN A NATURAL-POPULATION FROM TUBINGEN
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DOI：
10.1007/bf00222858
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发表时间：
1992-11-01
影响因子：
5.4
通讯作者：
SPERLICH, D
中科院分区：
文献类型：
--
作者：
FLEURIET, A;SPERLICH, D
在黑腹果蝇的自然种群中，通常有少数个体被称为 sigma 的弹状病毒感染。这种病毒不具有传染性，但通过配子垂直传播。在黑腹果蝇中，在野外经常观察到负责抗病毒的基因的两个等位基因（O，许可型和 P，限制性）的多态性。在病毒方面，发现了两种类型，它们对 P 等位基因的敏感性不同：I 型非常敏感，II 型更具抵抗力。先前的发现导致了这样的假设：从法国中部开始的 II 型克隆的入侵可能正在欧洲人群中蔓延。在朗格多克（法国南部）可以观察到自然群体中 I 型病毒被 II 型病毒取代，导致受感染果蝇的频率急剧增加。图宾根收集的样本数据证实了入侵假说，其中 II 型克隆的频率在 6 年期间（1985 年至 1991 年）从 0.27 增加到 0.93。然而，在同一时期，没有观察到受感染果蝇的频率增加。讨论了其他病毒特征的演变。
In natural populations of D. melanogaster, usually, a minority of individuals are infected by a Rhabdovirus called sigma. This virus is not contagious but is vertically transmitted through the gametes. In D. melanogaster, a polymorphism for two alleles (O, permissive and P, restrictive) of a gene responsible for resistance to the virus is regularly observed in the wild. On the virus side two types are found, which differ in their sensitivity to the P allele: Type I is very sensitive, and Type II more resistant. Previous findings had led to the hypothesis that an invasion of Type II clones, starting from central France, might be spreading over European populations. This replacement of viral Type I by viral Type II in natural populations could be observed in Languedoc (southern France), where it led to a dramatic increase in the frequency of infected flies. The invasion hypothesis is confirmed by the data from samples collected at Tubingen, where the frequency of Type II clones increased from 0.27 to 0.93 over a 6-year period (1985-1991). However, over the same period, no increase in the frequency of infected flies was observed. The evolution of other viral characteristics is discussed.