Moist and Mold Exposure is Associated With High Prevalence of Neurological Symptoms and MCS in a Finnish Hospital Workers Cohort
Moist and Mold Exposure is Associated With High Prevalence of Neurological Symptoms and MCS in a Finnish Hospital Workers Cohort
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DOI：
10.1016/j.shaw.2020.01.003
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发表时间：
2020-06-01
影响因子：
3.5
通讯作者：
Tuuminen, Tamara
中科院分区：
文献类型：
--
作者：
Hyvonen, Saija;Lohi, Jouni;Tuuminen, Tamara
背景：室内空气湿度微生物群（DM）是一大健康危害。有充分的证据表明，暴露于右美沙芬可引起新的哮喘或加重、呼吸困难、上呼吸道感染和过敏性肺泡炎。尚没有令人信服的证据表明湿和霉菌过敏综合征的肺外表现。方法：我们对赫尔辛基一家产科医院暴露于右美沙芬的护士和助产士队列（n = 90）进行问卷调查，调查除呼吸道症状外肺外的患病率。将相应的患病率与未暴露队列（n = 45）进行比较。特别感兴趣的是神经症状和多种化学敏感性。结果：研究组与对照组相比，呼吸道症状发生率更高，分别为80%和29%（风险比[RR]: 2.56, p < 0.001）。中枢或周围神经系统的症状在研究组与对照组中也更常见：81% vs 11% （RR: 6.63, p < 0.001）。在研究和对照队列中，分别有77对24% （RR: 3.05, p < 0.001）和40对9% （RR: 3.44, p = 0.01）报告了疲劳，所谓的“脑雾”在62对11% （RR: 4.94, p < 0.001）中普遍存在，57对2.4% （RR: 19.75, p < 0.001）报告了心律失常，51对22% （RR: 2.02, p = 0.02）报告了肌肉骨骼疼痛。结论：结果表明，暴露于DM与大量肺外症状有关。目前的数据证实了我们最近关于工作场所潮湿和霉菌暴露对健康影响的报告。(C) 2020职业安全与健康研究所，由爱思唯尔韩国有限责任公司出版。
Background: Indoor air dampness microbiota (DM) is a big health hazard. Sufficient evidence exists that exposure to DM causes new asthma or exacerbation, dyspnea, infections of upper airways and allergic alveolitis. Less convincing evidence has yet been published for extrapulmonary manifestations of dampness and mold hypersensitivity syndrome).Methods: We investigated the prevalence of extrapulmonary in addition to respiratory symptoms with a questionnaire in a cohort of nurses and midwives (n = 90) exposed to DM in a Helsinki Obstetric Hospital. The corresponding prevalence was compared with an unexposed cohort (n = 45). Particular interest was put on neurological symptoms and multiple chemical sensitivity.Results: The results show that respiratory symptoms were more common among participants of the study vs. control cohort, that is, 80 vs 29%, respectively (risk ratio [RR]: 2.56, p < 0.001). Symptoms of the central or peripheral nervous system were also more common in study vs. control cohort: 81 vs 11% (RR: 6.63, p < 0.001). Fatigue was reported in 77 vs. 24%, (RR: 3.05, p < 0.001) and multiple chemical sensitivity in 40 vs. 9%, (RR: 3.44, p = 0.01), the so-called "brain fog", was prevalent in 62 vs 11% (RR: 4.94, p < 0.001), arrhythmias were reported in 57 vs. 2.4% (RR: 19.75, p < 0.001) and musculoskeletal pain in 51 vs 22% (RR: 2.02, p = 0.02) among participants of the study vs. control cohort, respectively.Conclusion: The results indicate that the exposure to DM is associated with a plethora of extrapulmonary symptoms. Presented data corroborate our recent reports on the health effects of moist and mold exposure in a workplace. (C) 2020 Occupational Safety and Health Research Institute, Published by Elsevier Korea LLC.