Origin of facilitation in repetitive, 1.5 ms interval, paired pulse transcranial magnetic stimulation (rPPS) of the human motor cortex
Origin of facilitation in repetitive, 1.5 ms interval, paired pulse transcranial magnetic stimulation (rPPS) of the human motor cortex
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DOI：
10.1016/j.clinph.2007.03.009
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发表时间：
2007-07-01
影响因子：
4.7
通讯作者：
Ugawa, Yoshikazu
中科院分区：
文献类型：
--
作者：
Hamada, Masashi;Hanajima, Ritsuko;Ugawa, Yoshikazu
目的：以1.5 ins的刺激间隔（ISI）给予重复配对脉冲TMS（rPPS）已被报道可诱导持久的运动诱发电位（MEP）易化。该后效被认为是皮质事件，因为F波不受相同rPPS的影响。为了证实其皮层易化作用，我们比较了rPPS对运动皮层单脉冲经颅磁刺激（motor cortex MEPs）和脑干电刺激（brainstem MEPs）的后效作用。在ISI为1.5 ms的阈上配对脉冲TMS应用于运动皮层，以0.2 Hz的速率持续30 min。结果：rPPS干预后10 min运动皮层MEP易化至基线的190%（p < 0.001），干预后10-15 min恢复至基线水平。结论：间隔1.5ms的rPPS对MEN的易化作用发生在运动皮层，意义：间隔1.5ms的rPPS是增加运动皮层兴奋性的有效方法。(c)2007年国际临床神经生理学联合会。由Elsevier爱尔兰有限公司出版。保留所有权利。
Objective: Repetitive paired-pulse TMS (rPPS) given at an interstimulus interval (ISI) of 1.5 ins has been reported to induce a lasting motor evoked potential (MEP) facilitation. This after-effect was considered to be a cortical event because F-waves were not affected by the same rPPS. To confirm its cortical facilitation, we compared the after-effects of rPPS on MEPs to single pulse TMS over the motor cortex (motor cortical MEPs) with those to brainstem stimulation (brainstem MEPs).Methods: Subjects were 10 healthy volunteers. Suprathreshold paired-pulse TMS at an ISI of 1.5 ms was applied to the motor cortex for 30 min at a rate of 0.2 Hz. After intervention, we measured motor cortical MEPs for 30 min. We also studied brainstem MEPs in five subjects.Results: Motor cortical MEPs were facilitated to about 190% of baseline (p < 0.001) for 10 min post rPPS intervention and returned to the baseline at 10-15 min post intervention. Brainstem MEPs were not affected by the intervention.Conclusions: The facilitation of MEN after rPPS at an interval of 1.5 ms occurs at the motor cortex.Significance: rPPS at an interval of 1.5 ins is an effective method for increasing motor cortical excitability. (c) 2007 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.