Mechanisms underlying epigenetically mediated gene silencing in cancer
Mechanisms underlying epigenetically mediated gene silencing in cancer
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DOI：
10.1016/s1044-579x(02)00053-6
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发表时间：
2002-10-01
影响因子：
14.5
通讯作者：
Baylin, SB
中科院分区：
文献类型：
--
作者：
Baylin, SB
表观遗传介导的改变是人类癌症的一个基本特征，它建立了可遗传的基因表达异常。这些改变中研究最多的是异常基因沉默事件，涉及与异常甲基化启动子区CpG岛相关的转录失活。理解这种可能导致关键基因功能丧失的变化的一个最重要的方面是对介导转录抑制的分子机制的剖析，以及那些负责建立异常甲基化和相关染色质事件的分子机制。本章综述了这些领域的研究进展。表观遗传介导的改变是人类癌症的一个基本特征，它建立了可遗传的基因表达异常。这些改变中研究最多的是异常基因沉默事件，涉及与异常甲基化启动子区CpG岛相关的反式转录失活。理解这种可能导致关键基因功能丧失的变化的一个最重要的方面是对介导转录抑制的分子机制的剖析，以及那些负责建立异常甲基化和相关染色质事件的分子机制。本章回顾了这些领域的进展。
It has become apparent that epigenetically mediated alterations, which establish heritable abnormalities in gene, expression, are a fundamental feature of human cancer The best studied of these changes are aberrant gene silencing events which involve transcriptional inactivation associated with abnormally methylated promoter region CpG islands. A most important aspect of understanding this change, which can cause loss of key gene function, concerns dissection of the molecular mechanisms that mediate the transcriptional repression and those responsible for establishing the abnormal methylation and associated chromatin events. This chapter reviews the progress in these arenas.It has become apparent that epigenetically mediated alterations, which establish heritable abnormalities in gene, expression, are a fundanental feature of human cancer The best studied of these changes are aberrant gene silencing events which involve transriptional inactivation associated with abnormally methylated promoter region CpG islands. A most important aspect of understanding this change, which can cause loss of key gene function, concerns dissection of the molecular mechanisms that mediate the transriptional reppression and those responsible for establishing the abnormal methylation and associated chromatin events. This chapter reviews the progress in these arenas.