LOW ZERO-FLOW PRESSURE AND MINIMAL CAPACITANCE EFFECT ON DIASTOLIC CORONARY ARTERIAL PRESSURE-FLOW RELATIONSHIPS DURING MAXIMUM VASODILATION IN SWINE
LOW ZERO-FLOW PRESSURE AND MINIMAL CAPACITANCE EFFECT ON DIASTOLIC CORONARY ARTERIAL PRESSURE-FLOW RELATIONSHIPS DURING MAXIMUM VASODILATION IN SWINE
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DOI：
10.1161/01.cir.70.3.485
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发表时间：
1984-01-01
期刊：
影响因子：
37.8
通讯作者：
BRISTOW, JD
中科院分区：
文献类型：
--
作者：
PANTELY, GA;LADLEY, HD;BRISTOW, JD
在用腺苷对狗进行最大扩张期间，观察到血流停止时的舒张冠状动脉压力 (Pzf) 比冠状静脉窦和右心房压力高出 27 毫米汞柱。研究人员对猪进行了研究，测量 Pzf 并确定改变侧支血流和冠状动脉容量的干预措施的效果。在 44 头猪的左冠状动脉前降支 (LAD) 中安装了 2 根导管、一个液压封堵器和一个流量计。舒张晚期和平均压力-流量关系是在最大血管舒张期间部分 LAD 闭塞产生的一系列压力下构建的。舒张末期 Pzf 为 7.0 .+-。 2.2 毫米汞柱（平均值 .+-. SD），右心房压力以上 < 4 毫米汞柱；平均 Pzf 为 12.1.+-。 3.1 毫米汞柱，右心房压力以上 < 9 毫米汞柱。在 7 头猪的右冠状动脉 (RCA) 短暂同时闭塞期间，LAD 中的 Pzf 没有显着变化（RCA 打开时的舒张末期 Pzf 为 6.6 .+-. 1.5 mm Hg，RCA 关闭时为 6.0 .+-. 1.5 mm Hg），在 7 头猪的左心室收缩压 (LVSP) 增加期间（舒张末期 Pzf 为 6.0 .+-. 1.5 mm Hg）。 LVSP 为 123 mm Hg 时，Pzf 为 5.5 .+- 2.2 mm Hg，LVSP 为 184 mm Hg 时，Pzf 为 7.3 .+-2.8 mm Hg) 或在 8 只猪心率增加期间（心率为 107/min 时舒张末期 Pzf 为 10.8 .+-. 2.9 mm Hg）。 180/分钟，为 12.7±2.1 毫米汞柱）。通过分析平均压力和流量数据也得到了类似的结果。猪 LAD 中的 Pzf 非常接近右心房压力，并且在改变侧支血流（通过 RCA 闭塞减少并通过增加 LVSP 增强）和冠状动脉容量（增加 LVSP 和增加心率）的干预期间，它没有显着变化。这种低 Pzf 有利于在较低的冠状动脉灌注压下维持血流。
During maximum dilation with adenosine in dogs, the diastolic coronary pressure at which flow ceases (Pzf) has been observed to be up to 27 mm Hg above coronary sinus and right atrial pressures. Swine were studied to measure the Pzf and to determine the effects of interventions that change collateral flow and coronary capacitance. In 44 swine, the left anterior descending coronary artery (LAD) was instrumented with 2 catheters, a hydraulic occluder, and a flowmeter. Late diastolic and mean pressure-flow relationships were constructed at a series of pressures produced by partial LAD occlusions during maximum vasodilation. The late diastolic Pzf was 7.0 .+-. 2.2 mm Hg (mean .+-. SD), < 4 mm Hg above right atrial pressure; the mean Pzf was 12.1 .+-. 3.1 mm Hg, < 9 mm Hg above right atrial pressure. The Pzf in the LAD did not change significantly during transient simultaneous occlusion of the right coronary artery (RCA) in 7 swine (late diastolic Pzf with the RCA open was 6.6 .+-. 1.5 mm Hg and with the RCA closed it was 6.0 .+-. 1.5 mm Hg), during increased left ventricular systolic pressure (LVSP) in 7 swine (late diastolic Pzf with LVSP of 123 mm Hg was 5.5 .+-. 2.2 mm Hg and with LVSP of 184 mm Hg it was 7.3 .+-. 2.8 mm Hg) or during increased heart rate in 8 swine (late diastolic Pzf at heart rate of 107/min was 10.8 .+-. 2.9 mm Hg and at 180/min it was 12.7 .+-. 2.1 mm Hg). Similar results were obtained from analysis of the mean pressure and flow data. The Pzf in the LAD of swine is very close to right atrial pressure, and it did not change significantly during interventions that would modify collateral flow (reduced by RCA occlusion and enhanced by increased LVSP) and coronary capacitance (increased LVSP and increased heart rate). This low Pzf is beneficial in maintaining flow at lower coronary arterial perfusion pressures.