Memory of decisions: Relationship between decline of autobiographical memory and temporal discounting in Alzheimer's disease
Memory of decisions: Relationship between decline of autobiographical memory and temporal discounting in Alzheimer's disease
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DOI：
10.1080/13803395.2020.1744527
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发表时间：
2020-03-29
影响因子：
2.2
通讯作者：
Allain, Philippe
中科院分区：
文献类型：
--
作者：
El Haj, Mohamad;Boutoleau-Bretonniere, Claire;Allain, Philippe
时间折扣是指人们倾向于将更高的价值归因于早获得的奖励而不是晚获得的奖励。我们评估了阿尔茨海默病患者的这种倾向。我们还评估了时间折扣是否与自传体记忆的下降有关（即，记忆过去个人经历的能力）、执行功能障碍和/或一般认知衰退。我们邀请AD患者和对照组参与者回答二元问题，这些问题涉及在较早接受较少量的钱或较晚接受较大数额的钱之间的选择（例如，“你喜欢现在10欧元现金还是一个月后50欧元？").结果表明，AD患者的时间折扣高于对照组。AD患者的时间折扣与AM下降和一般认知下降显著相关，但与执行功能障碍无关。倾向于根据即时奖励（即，时间折扣）与难以记住关于先前决定的经历的信息，和/或它们的后果（即，自传体记忆衰退）。
Temporal discounting refers to the tendency to attribute higher value to a reward received early than to one received later. We evaluated this tendency in patients with Alzheimer's Disease. We also evaluated whether temporal discounting is associated with decline in autobiographical memory (i.e., the ability to remember past personal experiences), with executive dysfunction, and/or with general cognitive decline. We invited patients with AD and control participants to answer binary questions involving the choice between receiving a smaller amount of money earlier or a larger one later (e.g., "Which do you prefer, 10 euros in cash right now or 50 euros in a month?"). Results demonstrated higher temporal discounting in patients with AD than in control participants. Temporal discounting was significantly correlated with decline in AM and general cognitive decline but not with executive dysfunction in patients with AD. The tendency to decide based on immediate rewards (i.e., temporal discounting) in AD is related with difficulty in remembering information about experiences of previous decisions, and/or their consequences (i.e., decline in autobiographical memory).