PLASMA-CHOLESTEROL CONCENTRATION AND PRIMARY BRAIN-TUMORS
PLASMA-CHOLESTEROL CONCENTRATION AND PRIMARY BRAIN-TUMORS
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DOI：
10.1136/bmj.299.6690.26
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发表时间：
1989-07-01
影响因子：
105.7
通讯作者：
SHIPLEY, MJ
中科院分区：
文献类型：
--
作者：
SMITH, GD;SHIPLEY, MJ
先前的两项研究表明，男性血液中胆固醇浓度升高与原发性脑恶性肿瘤之间存在关联。在这两项研究中，对照组的选择都存在严重缺陷。此外，在这种回顾性研究中，疾病本身可能产生导致胆固醇浓度升高的行为或生理变化。因此，我们在一项大型队列研究中研究了血浆胆固醇浓度与脑癌死亡率之间的关系。
Two previous studies have shown a relation between raised blood cholesterol concentration and primary brain malignancies in men.'7 In both studies the selection of controls was seriously flawed. Furthermore, in such retrospective studies the disease itself may have produced behavioural or physiological changes that resulted in raised cholesterol concentrations. We therefore examined the association between plasma cholesterol concentration and mortality from brain cancer in a large cohort study.