Natural aporphine alkaloids: A comprehensive review of phytochemistry, pharmacokinetics, anticancer activities, and clinical application
Natural aporphine alkaloids: A comprehensive review of phytochemistry, pharmacokinetics, anticancer activities, and clinical application
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天然阿朴吗啡生物碱：植物化学、药代动力学、抗癌活性及临床应用综述
DOI：
10.1016/j.jare.2023.11.003
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发表时间：
2024-08-18
影响因子：
10.7
通讯作者：
Yang，Haixia
中科院分区：
文献类型：
--
作者：
Sun，Jing;Zhan，Xingtian;Yang，Haixia
背景癌症是人类最常见的死亡原因，也是一个严重的公共卫生问题。生物碱是一类广泛存在于植物尤其是中草药中的生物活性化合物，在食品和临床上被用作功能性成分、前体和先导化合物。其中阿朴啡生物碱（AAs）作为一类重要的异喹啉类生物碱，对多种肿瘤具有较强的抗癌作用。本文综述了七种不同植物来源的氨基酸及其衍生物的化学结构和生物利用度，并重点介绍了它们的抗癌生物活性和作用机制。阐明了AA的多样性，并强调了关于AA及其衍生物的有效抗癌活性的有希望的结果，有助于其药理学益处。这项工作提供了一个更好的了解AA和联合抗癌治疗涉及他们，从而提高功能性食品的开发含有植物源性AA和AA的临床应用。
BackgroundCancer is the most common cause of death and is still a serious public health problem. Alkaloids, a class of bioactive compounds widely diffused in plants, especially Chinese herbs, are used as functional ingredients, precursors, and lead compounds in food and clinical applications. Among them, aporphine alkaloids (AAs), as an important class of isoquinoline alkaloids, exert a strong anticancer effect on multiple cancer types.Aim of reviewThis review aims to comprehensively summarize the phytochemistry, pharmacokinetics, and bioavailability of seven subtypes of AAs and their derivatives from various plants and highlight their anticancer bioactivities and mechanisms of action.Key Scientific Concepts of Review.The chemical structures and botanical diversity of AAs are elucidated, and promising results are highlighted regarding the potent anticancer activities of AAs and their derivatives, contributing to their pharmacological benefits. This work provides a better understanding of AAs and combinational anticancer therapies involving them, thereby improving the development of functional food containing plant-derived AA and the clinical application of AAs.