Lewy body-type degeneration in cardiac plexus in Parkinson's and incidental Lewy body diseases
Lewy body-type degeneration in cardiac plexus in Parkinson's and incidental Lewy body diseases
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DOI：
10.1212/wnl.52.6.1269
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发表时间：
1999-04-12
期刊：
影响因子：
9.9
通讯作者：
Takahashi, H
中科院分区：
文献类型：
--
作者：
Iwanaga, K;Wakabayashi, K;Takahashi, H
应用光镜和电镜观察PD和偶发性路易体病（ILBD）患者的心脏组织。LB和α-突触核蛋白阳性神经突在9/11例PD患者和7/7例ILBD患者的心脏中被鉴定。LB存在于酪氨酸：羟化酶阳性和阴性的神经过程，这是神经的外在交感神经和内在起源，分别。这些发现提供了组织学证据，表明心脏中的节后交感神经元和固有神经元参与了PD疾病过程。
Heart tissues of patients with PD or incidental Lewy body (LB) disease (ILBD) were examined by light and electron microscopy. LBs and alpha-synuclein-positive neurites were identified in the hearts from 9 of 11 patients with PD and from 7 of 7 patients with ILBD. LBs were present in both tyrosine: hydroxylase-positive and -negative nerve processes, which are nerves of extrinsic sympathetic and intrinsic origin, respectively. These findings provide histologic evidence that the postganglionic sympathetic and intrinsic neurons in the heart are involved in the PD disease process.