Beyond the RNA-dependent function of LncRNA genes.
Beyond the RNA-dependent function of LncRNA genes.
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DOI：
10.7554/elife.60583
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发表时间：
2020-10-23
期刊：
影响因子：
7.7
通讯作者：
Grote P
中科院分区：
文献类型：
--
作者：
Ali T;Grote P
虽然长链非编码RNA（lncRNA）基因在过去十年中吸引了很多关注，但关于其作用机制的焦点主要集中在这些基因的RNA产物上。最近对几种lncRNA基因的研究表明，不仅产生的RNA种类很重要，而且lncRNA基因座的转录也可以具有调节功能。与lncRNA转录物的功能一样，这些基于基因组的功能的机制也是多种多样的。在这里，我们强调了一些这样的例子，并提供了一个如何确定lncRNA基因的功能机制的前景。
While long non-coding RNA (lncRNA) genes have attracted a lot of attention in the last decade, the focus regarding their mechanisms of action has been primarily on the RNA product of these genes. Recent work on several lncRNAs genes demonstrates that not only is the produced RNA species important, but also that transcription of the lncRNA locus alone can have regulatory functions. Like the functions of lncRNA transcripts, the mechanisms that underlie these genome-based functions are varied. Here we highlight some of these examples and provide an outlook on how the functional mechanisms of a lncRNA gene can be determined.