Enhancement of splenic glucose metabolism during acute malarial infection: Correlation of findings of FDG-PET imaging with pathological changes in a primate model of severe human malaria
Enhancement of splenic glucose metabolism during acute malarial infection: Correlation of findings of FDG-PET imaging with pathological changes in a primate model of severe human malaria
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DOI：
10.4269/ajtmh.2006.74.353
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发表时间：
2006-03-01
影响因子：
3.3
通讯作者：
Suzuki, M
中科院分区：
文献类型：
--
作者：
Kawai, S;Ikeda, E;Suzuki, M
在目前的研究中，阐明严重疟疾的临床特征，我们进行了全身正电子发射断层扫描（PET）与F-18-氟脱氧葡萄糖（FDG）的疟原虫感染急性期日本猕猴。感染猴脾脏FDG摄取明显增加，表明葡萄糖代谢明显增强。感染猴脾脏的标准化摄取值（SUV）显著高于未感染猴。尸检时，所有感染猴均明显存在脾肿大，组织病理学结果包括白色髓中淋巴滤泡增生、大量活化的巨噬细胞以及红髓中寄生红细胞（PRBC）和疟疾色素充血。因此，我们认为脾脏葡萄糖摄取的增加可能与脾脏清除系统对血液期疟原虫的激活密切相关。
In the current study, to elucidate the clinical features of severe malaria, we performed whole-body positron emission tomography (PET) with F-18-fluorodeoxyglucose (FDG) of Plasmodium coatneyi-infected acute-phase Japanese macaques. The infected monkeys clearly exhibited increase in splenic FDG uptake indicating marked enhancement of glucose metabolism. The standardized uptake values (SUVs) of the spleen in the infected monkeys were significantly higher than those in the uninfected monkey. At autopsy, splenomegaly was clearly present in all infected monkeys, and histopathologic findings included hyperplasia of lymphoid follicles in white pulp, a large number of activated macrophage, and congestion of parasitized red blood cells (PRBCs) and malaria pigments in red pulp. We suggest that increase in splenic glucose uptake may thus be closely related to activation of splenic clearance system against blood-stage malarial parasites.