Modeling hepatitis C virus infection using human induced pluripotent stem cells
Modeling hepatitis C virus infection using human induced pluripotent stem cells
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DOI：
10.1073/pnas.1121400109
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发表时间：
2012-02-14
影响因子：
11.1
通讯作者：
Bhatia, Sangeeta N.
中科院分区：
文献类型：
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作者：
Schwartz, Robert E.;Trehan, Kartik;Bhatia, Sangeeta N.
人类病原体通过与宿主复杂的相互作用影响患者健康，但研究宿主遗传学在这一过程中的作用的模型有限。人诱导多能干细胞（iPSCs）提供了产生宿主特异性分化细胞的能力，因此有可能改变传染病的研究；然而，没有描述过传染病的iPSC模型。在这里，我们报道了来自iPSCs的肝细胞样细胞支持丙型肝炎病毒的整个生命周期，包括对感染的炎症反应，从而使宿主遗传学如何影响病毒发病机制的研究成为可能。
Human pathogens impact patient health through a complex interplay with the host, but models to study the role of host genetics in this process are limited. Human induced pluripotent stem cells (iPSCs) offer the ability to produce host-specific differentiated cells and thus have the potential to transform the study of infectious disease; however, no iPSC models of infectious disease have been described. Here we report that hepatocyte-like cells derived from iPSCs support the entire life cycle of hepatitis C virus, including inflammatory responses to infection, enabling studies of how host genetics impact viral pathogenesis.