Nanoparticles for cancer imaging: The good, the bad, and the promise.
Nanoparticles for cancer imaging: The good, the bad, and the promise.
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DOI：
10.1016/j.nantod.2013.06.001
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发表时间：
2013-10
期刊：
影响因子：
17.4
通讯作者：
Yang L
中科院分区：
文献类型：
--
作者：
Chapman S;Dobrovolskaia M;Farahani K;Goodwin A;Joshi A;Lee H;Meade T;Pomper M;Ptak K;Rao J;Singh R;Sridhar S;Stern S;Wang A;Weaver JB;Woloschak G;Yang L
分子成像和纳米技术的最新进展为生物医学成像提供了新的机会，并为新型成像剂的开发带来了巨大的希望。纳米级材料的独特光学、磁性和化学性质允许创建具有更好的对比度增强、更高的灵敏度、受控的生物分布、更好的空间和时间信息、跨MRI、PET、SPECT和超声的多功能和多模式成像的成像探针。这些功能最终可以转化为临床优势，如早期检测，疾病进展的真实的时间评估和个性化医疗。然而，对这些材料在癌症研究中的应用进行了几年的调查，揭示了延迟这些药物在生物医学成像领域成功应用的挑战。了解这些挑战对于充分利用纳米尺寸成像剂提供的益处至关重要。因此，本文介绍了一组领先的研究人员在这一领域所吸取的教训和遇到的挑战，并提出了发展纳米粒子探针用于癌症成像的方法。爱思唯尔有限公司出版
Recent advances in molecular imaging and nanotechnology are providing new opportunities for biomedical imaging with great promise for the development of novel imaging agents. The unique optical, magnetic, and chemical properties of materials at the scale of nanometers allow the creation of imaging probes with better contrast enhancement, increased sensitivity, controlled biodistribution, better spatial and temporal information, multi-functionality and multi-modal imaging across MRI, PET, SPECT, and ultrasound. These features could ultimately translate to clinical advantages such as earlier detection, real time assessment of disease progression and personalized medicine. However, several years of investigation into the application of these materials to cancer research has revealed challenges that have delayed the successful application of these agents to the field of biomedical imaging. Understanding these challenges is critical to take full advantage of the benefits offered by nano-sized imaging agents. Therefore, this article presents the lessons learned and challenges encountered by a group of leading researchers in this field, and suggests ways forward to develop nanoparticle probes for cancer imaging. Published by Elsevier Ltd.