Influenza viruses resistant to the antiviral drug oseltamivir: Transmission studies in ferrets
Influenza viruses resistant to the antiviral drug oseltamivir: Transmission studies in ferrets
复制标题
DOI：
10.1086/424572
复制
发表时间：
2004-11-01
影响因子：
6.4
通讯作者：
Monto, AS
中科院分区：
文献类型：
--
作者：
Herlocher, ML;Truscon, R;Monto, AS
已分离出三种A型流感病毒，每种病毒都有不同的神经氨酸酶基因突变，并对神经氨酸酶抑制剂奥司他韦具有耐药性。以前，在雪貂模型中，A型（H3N2）病毒的R292K突变体在野生型病毒传播的条件下不会传播。该模型用于研究A型（H3N2）病毒的E119V突变体和A型（H1N1）病毒的H274Y突变体是否会在类似情况下传播。这两种突变病毒都能传播，尽管H274Y突变体需要100倍的剂量才能感染供体雪貂，而且传播速度比野生型慢。突变体和野生型病毒都保留了它们的基因型特征。
Three type A influenza viruses, each of which has a distinct neuraminidase-gene mutation and is resistant to the neuraminidase inhibitor oseltamivir, have been isolated. Previously, in the ferret model, an R292K mutant of a type A (H3N2) virus was not transmitted under conditions in which the wild-type virus was transmitted. This model was used to investigate whether the E119V mutant of a type A ( H3N2) virus and the H274Y mutant of a type A (H1N1) virus would be transmitted under similar circumstances. Both mutant viruses were transmitted, although the H274Y mutant required a 100-fold-higher dose for infection of donor ferrets and was transmitted more slowly than was the wild type. Both the mutant and the wild-type viruses retained their genotypic characteristics.