Biochemical characterization of Campylobacter fetus lipopolysaccharides.
Biochemical characterization of Campylobacter fetus lipopolysaccharides.
复制标题
胎儿弯曲杆菌脂多糖的生化特征。
DOI：
10.1016/0928-8244(96)00043-0
复制
发表时间：
1994
影响因子：
3.1
通讯作者：
I. Helander
中科院分区：
文献类型：
--
作者：
A. Moran;D. T. O'Malley;T. Kosunen;I. Helander
胎儿弯曲杆菌（Campylobacter fetus and venerealis）是一种重要的兽医细菌，也是引起人类各种感染的原因，本文对三种菌株的脂多糖（LPS）诱导有丝分裂、鲎变形细胞溶解物凝胶化、小鼠致死毒性和家兔致热原性进行了评价。所有C。胎儿LPS活性低于鼠伤寒沙门氏菌LPS。C.胎儿血清型A亚种在所有测定中具有最低活性。由于大多数C。由于人胎儿亚种分离物是血清型A，这种LPS的较低生物活性可能有助于这些菌株的发病。C.胎儿LPS组与S.伤寒沙门氏菌LPS可能反映了脂质A或C中存在较长的脂肪酸链。胎儿LPS，而C.胎儿LPS的生物活性可能与某些受糖部分组成影响的性质有关。
Lipopolysaccharides (LPS) of three strains ofCampylobacter fetus(subspp.fetusandvenerealis, and serotypes A and B), a bacterium of veterinary importance but also a cause of various infections in humans, were assessed for their ability to induce mitogenicity, gelation ofLimulusamebocyte lysate, lethal toxicity in mice, and pyrogenicity in rabbits. AllC. fetusLPS exhibited activities lower than those ofSalmonella typhimuriumLPS. LPS ofC. fetussubsp.fetusserotype A had the lowest activity in all assays. Since the majority ofC. fetussubsp.fetusisolates from humans are serotype A, the lower biological activities of this LPS may aid the pathogenesis of such strains. The lower activities ofC. fetusLPS compared with those ofS. typhimuriumLPS may reflect the presence of longer fatty acid chains in the lipid A ofC. fetusLPS, whereas interstrain differences inC. fetusLPS bioactivities may be related to some property influenced by composition of the saccharide moiety.