Prospective study on the association between dietary non-enzymatic antioxidant capacity and depressive symptoms
Prospective study on the association between dietary non-enzymatic antioxidant capacity and depressive symptoms
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DOI：
10.1016/j.clnesp.2020.01.010
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发表时间：
2020-04-01
影响因子：
3
通讯作者：
Mizoue, Tetsuya
中科院分区：
文献类型：
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作者：
Miki, Takako;Eguchi, Masafumi;Mizoue, Tetsuya
背景和目标：氧化应激被认为在抑郁症的病理生理学中起着重要作用，高抗氧化剂的饮食可能会改善情绪。然而，针对这一问题的研究很少。这项队列研究的目的是调查日本员工整体饮食中的饮食非酶抗氧化能力（NEAC）与抑郁症状之间的前瞻性关联。此外，我们研究了饮食NEAC sources.Method分离的关联：参与者是911名工人在基线时没有抑郁症状，并参加了3年的随访调查。膳食NEAC测定从数据库的NEAC测量获得的铁还原抗氧化能力（FRAP）和氧自由基吸收能力（ORAC）。膳食NEAC的计算方法是将估计的NEAC值乘以摄入量，然后将这些值相加。使用流行病学研究中心抑郁量表评估抑郁症状。Logistic回归估计抑郁症状的优势比，根据整体NEAC和单独的食品和饮料。结果：在3年的随访，153（16.8%）工人被新确定为有抑郁症状。在调整潜在混杂因素后，未发现较高水平的总体饮食NEAC与抑郁症状风险降低之间存在显著相关性（总体：FRAP，趋势P = 0.19，ORAC，趋势P = 0.20）。同样，无论是较高的饮食NEAC从食品或饮料与较低的抑郁症状。结论：我们的研究结果并不支持饮食NEAC和抑郁症状的风险在日本工人之间的负相关。(C)2020年，任作家。由Elsevier Ltd代表欧洲临床营养与代谢学会发布。
Background & aims: Oxidative stress has been suggested to play an important role in the pathophysiology of depression, and a diet high in antioxidants may improve mood. However, studies addressing this issue are scarce. The aim of this cohort study was to investigate the prospective association between dietary non-enzymatic antioxidant capacity (NEAC) in overall diet and depressive symptoms in Japanese employees. Additionally, we examined the association separated by dietary NEAC sources.Method: Participants were 911 workers without depressive symptoms at baseline and participated in 3-y follow-up survey. Dietary NEAC was determined from a database of NEAC measurements obtained by ferric reducing antioxidant power (FRAP) and oxygen radical absorbance capacity (ORAC). Dietary NEAC was calculated by multiplying the estimated NEAC values with the consumed amount and summing up those values. Depressive symptoms were assessed using the Center for Epidemiologic Studies Depression Scale. Logistic regression was used to estimate odds ratios of depressive symptoms according to overall NEAC and separately from foods and beverages.Results: At 3-y follow-up, 153 (16.8%) workers were newly identified as having depressive symptom. No significant associations were found between higher level of overall dietary NEAC and decreased risk of depressive symptoms after adjustment for potential confounders (overall: FRAP, P for trend = 0.19 and ORAC, P for trend = 0.20). Likewise, neither higher dietary NEAC from foods nor beverages were related with lower depressive symptoms.Conclusion: Our findings did not support an inverse association between dietary NEAC and the risk of depressive symptoms in Japanese workers. (C) 2020 The Authors. Published by Elsevier Ltd on behalf of European Society for Clinical Nutrition and Metabolism.