Global stability of a diffusive and delayed virus infection model with general incidence function and adaptive immune response
Global stability of a diffusive and delayed virus infection model with general incidence function and adaptive immune response
复制标题
具有一般发生函数和适应性免疫反应的扩散和延迟病毒感染模型的全局稳定性
DOI:
10.1007/s40314-017-0543-9
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发表时间:
2017-11-30
影响因子:
2.6
通讯作者:
Li Z
中科院分区:
文献类型:
--
作者:
Miao H;Teng Z;Abdurahman X;Li Z
In this paper, the dynamical behaviors for a five-dimensional virus infection model with diffusion and two delays which describes the interactions of antibody, cytotoxic T-lymphocyte (CTL) immune responses and a general incidence function are investigated. The reproduction numbers for virus infection, antibody immune response, CTL immune response, CTL immune competition and antibody immune competition, respectively, are calculated. By using the Lyapunov functionals and linearization methods, the threshold conditions on the global stability of the equilibria for infection-free, immune-free, antibody response, CTL response and antibody and CTL responses, respectively, are established if the space is assumed as homogeneous. When the space is inhomogeneous, the effects of diffusion, intracellular delay and production delay are obtained by the numerical simulations.
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