Global stability of a diffusive and delayed virus infection model with general incidence function and adaptive immune response

Global stability of a diffusive and delayed virus infection model with general incidence function and adaptive immune response
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具有一般发生函数和适应性免疫反应的扩散和延迟病毒感染模型的全局稳定性

DOI:
10.1007/s40314-017-0543-9
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发表时间:
2017-11-30
影响因子:
2.6
通讯作者:
Li Z
Li Z
中科院分区:
数学4区
文献类型:
--
作者:
Miao H;Teng Z;Abdurahman X;Li Z

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研究了一类具有扩散和双时滞的五维病毒感染模型的动力学行为,该模型描述了抗体、细胞毒性T淋巴细胞(CTL)免疫反应和一般的传染函数之间的相互作用.分别计算了病毒感染、抗体免疫应答、CTL免疫应答、CTL免疫竞争和抗体免疫竞争的繁殖数。利用李雅普诺夫泛函和线性化方法,分别建立了无感染、无免疫、抗体反应、CTL反应以及抗体和CTL反应平衡点全局稳定的阈值条件.在非齐次空间中,通过数值模拟得到了扩散、胞内时滞和生产时滞的影响。
In this paper, the dynamical behaviors for a five-dimensional virus infection model with diffusion and two delays which describes the interactions of antibody, cytotoxic T-lymphocyte (CTL) immune responses and a general incidence function are investigated. The reproduction numbers for virus infection, antibody immune response, CTL immune response, CTL immune competition and antibody immune competition, respectively, are calculated. By using the Lyapunov functionals and linearization methods, the threshold conditions on the global stability of the equilibria for infection-free, immune-free, antibody response, CTL response and antibody and CTL responses, respectively, are established if the space is assumed as homogeneous. When the space is inhomogeneous, the effects of diffusion, intracellular delay and production delay are obtained by the numerical simulations.
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