Ribosomal Synthesis of Peptides with C‐Terminal Lactams, Thiolactones, and Alkylamides
Ribosomal Synthesis of Peptides with C‐Terminal Lactams, Thiolactones, and Alkylamides
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DOI：
10.1002/cbic.200900058
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发表时间：
2009-05
期刊：
影响因子：
3.2
通讯作者：
Eiji Nakajima;Yuki Goto;Yusuke Sako;H. Murakami;H. Suga
中科院分区：
文献类型：
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作者：
Eiji Nakajima;Yuki Goto;Yusuke Sako;H. Murakami;H. Suga
C末端的所有变化：我们已经建立了一种新的方法，通过利用遗传密码重编程来合成具有C末端环化和包括大环化在内的各种修饰的多肽的核糖体。线状和环状多肽的C-端酰胺修饰可以提高它们的生理稳定性，并为开发新的类药物多肽开辟了可能性。
All change at the C terminus: We have established a novel methodology for the ribosomal synthesis of peptides featuring C‐terminal cyclization and various modifications, including macrocyclization, by making use of genetic code reprogramming. The C‐terminal amide modification of linear and cyclic peptides should enhance their physiological stabilities, and open up the possibility of developing new drug‐like peptides.