Genetic and environmental influences on decline in biobehavioral markers of aging
Genetic and environmental influences on decline in biobehavioral markers of aging
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DOI：
10.1023/a:1022549700943
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发表时间：
2003-03-01
影响因子：
2.6
通讯作者：
Svartengren, M
中科院分区：
文献类型：
--
作者：
Finkel, D;Pedersen, NL;Svartengren, M
将潜在生长模型应用于衰老标志物的纵向孪生数据，以考察遗传和环境对随年龄变化过程的影响。样本包括1957名年龄在50岁到96岁之间的参与者。评估了五项指标：用力呼气量、平均动脉压、握力、运动功能和幸福感。每隔3年，在最多3次随访中收集数据。结果表明，除了两个变量外，所有变量都随着年龄的增长而单调变化。运动功能和幸福感方面的表现在65岁或70岁之前是稳定的，随后显著下降。所有五个衰老标志都表明了遗传对表现水平的影响。只有三个变量对斜率有遗传影响：运动功能、平均动脉压和用力呼气量。对老化过程的研究将根据重点是静态性能还是变化而有所不同。
Latent growth models were applied to longitudinal twin data on markers of aging to investigate genetic and environmental influences on the processes of change with age. The sample included 1957 participants aged 50 to 96 years. Five markers were assessed: forced expiratory volume, mean arterial pressure, grip strength, motor functioning, and well-being. Data were gathered at up to three follow-up occasions at intervals of 3 years. Results indicated monotonic changes with age for all but two variables. Performance on motor functioning and well-being was stable until age 65 or 70, followed by significant decline. Genetic influences on the level of performance were indicated for all five markers of aging. Genetic influences on the slope were found for only three of the variables: motor functioning, mean arterial pressure, and forced expiratory volume. Investigations of the aging process will differ depending on whether the focus is on static performance or change.