Ruthenium-catalyzed C-H Silylation of Methylboronic Acid Using a Removable α-Directing Modifier on the Boron Atom
Ruthenium-catalyzed C-H Silylation of Methylboronic Acid Using a Removable α-Directing Modifier on the Boron Atom
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DOI：
10.1246/cl.2011.916
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发表时间：
2011-09-05
影响因子：
1.6
通讯作者：
Suginome, Michinori
中科院分区：
文献类型：
--
作者：
Ihara, Hideki;Ueda, Akinori;Suginome, Michinori
通过使用 2-(1H-吡唑-3-基)苯胺作为硼原子上可去除的 α 导向改性剂，实现了钌催化的甲基硼酸的 C-H 甲硅烷基化。产物（苯基二甲基甲硅烷基）甲基频哪醇硼烷与芳基卤化物的交叉偶联在 [PdCl2(dppf)] 催化剂和 CsOH 作为碱的存在下进行。
Ruthenium-catalyzed C-H silylation of methylboronic acid was achieved by use of 2-(1H-pyrazol-3-yl)aniline as a removable alpha-directing modifier on the boron atom. Cross-coupling of the product, i.e., (phenyldimethylsilyl)methylpinacolborane, with aryl halides proceeded in the presence of a [PdCl2(dppf)] catalyst and CsOH as a base.