Pubertal Testosterone Tracks the Developmental Trajectory of Neural Oscillatory Activity Serving Visuospatial Processing
Pubertal Testosterone Tracks the Developmental Trajectory of Neural Oscillatory Activity Serving Visuospatial Processing
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DOI：
10.1093/cercor/bhaa169
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发表时间：
2020-11-01
期刊：
影响因子：
3.7
通讯作者：
Wilson, Tony W.
中科院分区：
文献类型：
--
作者：
Fung, Madison H.;Taylor, Brittany K.;Wilson, Tony W.
青春期是一个激素大幅波动的时期，会引发显著的生理、神经和行为变化。先前的研究表明，青春期激素会调节皮质发育，以及儿童期和青春期特定性别和年龄的认知发展模式。然而，青春期激素对大脑功能发育，特别是神经振荡动力学的影响尚未得到充分研究。因此，在当前的研究中，我们使用脑磁图来研究服务于视觉空间感知和注意力的振荡动力学，并将睾酮水平和实际年龄作为发育的衡量指标。在一组正常发育的青少年样本中，年龄与α、θ和γ振荡活动的变化有关。在视觉和注意力网络的关键区域发现了γ频段新的睾酮与性别的交互作用。女性在右侧颞顶联合区和枕叶皮质中，随着睾酮水平的升高，γ活动增强，而男性在右侧脑岛随着睾酮水平的升高，γ活动增强。这些发现揭示了儿童期和青春期服务于视觉空间处理的振荡动力学的显著发育变化，并为青春期过渡期间功能性大脑发育的性别二态性模式的激素基础提供了新的见解，这种性别二态性模式至少部分是由内源性睾酮介导的。
Puberty is a period of substantial hormonal fluctuations that induce dramatic physical, neurological, and behavioral changes. Previous research has demonstrated that pubertal hormones modulate cortical development, as well as sex- and age-specific patterns of cognitive development during childhood and adolescence. However, the influence of pubertal hormones on the brain's functional development, specifically neural oscillatory dynamics, has yet to be fully examined. Thus, in the current study, we used magnetoencephalography to investigate the oscillatory dynamics serving visuospatial perception and attention, and testosterone levels and chronological age as measures of development. Within a sample of typically developing youth, age was associated with changes in alpha, theta, and gamma oscillatory activity. Novel testosterone-by-sex interactions in the gamma range were identified in critical areas of the visual and attention networks. Females had increased gamma activity with increasing testosterone in the right temporal-parietal junction and occipital cortices, while males showed increased gamma activity in the right insula with increasing testosterone. These findings reveal robust developmental alterations in the oscillatory dynamics serving visuospatial processing during childhood and adolescence and provide novel insight into the hormonal basis of sexually dimorphic patterns of functional brain development during the pubertal transition that is at least partially mediated by endogenous testosterone.