A highly selective and sensitive turn-on probe for aluminum(III) based on quinoline Schiff's base and its cell imaging.
A highly selective and sensitive turn-on probe for aluminum(III) based on quinoline Schiff's base and its cell imaging.
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DOI：
10.1016/j.saa.2017.09.007
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发表时间：
2018-02
期刊：
影响因子：
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通讯作者：
Fenfen Zhou;Hongqing Wang;Pengying Liu;Qinghua Hu;Yuyuan Wang;Can Liu;Jiang-Bo Hu
中科院分区：
文献类型：
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作者：
Fenfen Zhou;Hongqing Wang;Pengying Liu;Qinghua Hu;Yuyuan Wang;Can Liu;Jiang-Bo Hu
设计、合成并评价了一种基于喹啉衍生物的Al ~（3+）的可逆Schiff碱荧光探针3，5-二氯-2-羟基苯亚甲基喹啉-2-碳酰肼（QC）。在乙醇-水（v/v = 1：9，pH = 6）介质中，该试剂与Al ~（3+）形成1：1的络合物，对Al ~（3+）具有很高的灵敏度和选择性，检出限为0.012 μM。实验结果表明，F-破坏了Al ~（3+）与QC单键的结合，因此该体系可用于F-的监测。QC荧光增强的原因可能是Al ~（3+）对PET和ESIPT的抑制以及对CHEF过程的应急。更重要的是，该方法不仅成功地用于自来水和人血清中微量Al ~（3+）的测定，而且对Hela细胞中Al ~（3+）的荧光成像也是有效的。
A reversible Schiff's base fluorescence probe for Al3+, (3,5-dichloro-2- hydroxybenzylidene) quinoline-2-carbohydrazide (QC), based on quinoline derivative has been designed, synthesized and evaluated. TheQCexhibited a high sensitivity and selectivity toward Al3+in EtOH-H2O (v/v = 1:9, pH = 6) by forming a 1:1 complex with Al3+and the detection limit ofQCfor Al3+was as low as 0.012 μM. Furthermore, these results displayed that the binding ofQCsingle bondAl3+was broken by F−, so this system could be used to monitor F−in the future. The enhancement fluorescence of theQCcould be attributed to the inhibition of PET and ESIPT and the emergency of CHEF process induced by Al3+. More importantly,QCwas not only successfully used for the determination of trace Al3+in the tap water and the human blood serum, but was valid for fluorescence imaging of Al3+in the Hela cells.