Hyperinsulinemia and elevated blood pressure: cause, confounder, or coincidence?
Hyperinsulinemia and elevated blood pressure: cause, confounder, or coincidence?
复制标题
DOI：
10.1093/oxfordjournals.aje.a115725
复制
发表时间：
1990-11
影响因子：
5
通讯作者：
R. Donahue;J. Skyler;N. Schneiderman;R. Prineas
中科院分区：
文献类型：
--
作者：
R. Donahue;J. Skyler;N. Schneiderman;R. Prineas
评估一个假定的风险因素与临床终点或疾病之间的关系，充其量是一项困难的事业。两个变量可能由于偶然性或混杂因素（第三个变量与风险因素和疾病的关联）或因为它们在因果通路中相关联而相关联。虽然随机临床试验最适合区分这些可能性，但在实践中，它们往往是不可行的，人们必须依赖于观察证据的累积权重。与此相关的多种风险因素
Evaluating the relation between a putative risk factor and a clinical endpoint or disease is, at best, a difficult enterprise. Two variables may be associated because of chance or confounding (the association of a third variable with both the risk factor and disease) or because they are linked in a causal pathway. While randomized clinical trials are best suited to distinguishing among these possibilities, in practice they are often not feasible, and one must rely instead on the accumulated weight of the observational evidence. The multiple risk factors associated with