Wnt signalling in stem cells and cancer
Wnt signalling in stem cells and cancer
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DOI：
10.1038/nature03319
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发表时间：
2005-04-14
期刊：
影响因子：
64.8
通讯作者：
Clevers, H
中科院分区：
文献类型：
--
作者：
Reya, T;Clevers, H
经典的Wnt级联已经成为干细胞的关键调节因子。在许多组织中，Wnt信号传导的激活也与癌症相关。这提出了这样的可能性，即在干细胞和祖细胞中由Wnt信号传导介导的严格调节的自我更新在癌细胞中被破坏以允许恶性增殖。从了解Wnt通路如何整体参与干细胞和癌细胞在肠道，表皮和造血系统中的维持和生长中获得的见解可以作为理解自我更新信号的双重性质的范例。
The canonical Wnt cascade has emerged as a critical regulator of stem cells. In many tissues, activation of Wnt signalling has also been associated with cancer. This has raised the possibility that the tightly regulated self-renewal mediated by Wnt signalling in stem and progenitor cells is subverted in cancer cells to allow malignant proliferation. Insights gained from understanding how the Wnt pathway is integrally involved in both stem cell and cancer cell maintenance and growth in the intestinal, epidermal and haematopoietic systems may serve as a paradigm for understanding the dual nature of self-renewal signals.