Urinary single-cell transcriptomics: a promising noninvasive method for assessing acute kidney injury
Urinary single-cell transcriptomics: a promising noninvasive method for assessing acute kidney injury
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尿液单细胞转录组学：一种有前途的评估急性肾损伤的无创方法
DOI：
10.1016/j.kint.2022.09.006
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发表时间：
2022
影响因子：
19.6
通讯作者：
Hasegawa Sho
中科院分区：
文献类型：
--
作者：
Inagi Reiko;Hasegawa Sho;Hasegawa Sho
为了了解急性肾损伤（阿基）的发病机制，需要无创的方法来获得肾内信息。Klockeet al.探索了使用尿单细胞RNA测序评估人阿基的可行性。来自阿基患者的尿液样本包括具有损伤相关的去分化和适应性表型的肾小管上皮细胞，其可以反映肾组织损伤。因此，尿单细胞RNA测序将为人类阿基提供新的见解，从而识别新的生物标志物和治疗靶点。
Noninvasive methods for obtaining intrarenal information are required to understand the mechanism of acute kidney injury (AKI). Klockeet al.explored the feasibility of using urinary single-cell RNA sequencing in assessing human AKI. Urine samples from patients with AKI included tubular epithelial cells with injury-related dedifferentiation and adaptive phenotypes, which could reflect kidney tissue damage. Thus, urinary single-cell RNA sequencing would provide new insights into human AKI, leading to the identification of novel biomarkers and therapeutic targets.