Effects of the val(158)met catechol-O-methyltransferase gene polymorphism on olfactory processing in schizophrenia.
Effects of the val(158)met catechol-O-methyltransferase gene polymorphism on olfactory processing in schizophrenia.
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val(158)met儿茶酚-O-甲基转移酶基因多态性对精神分裂症嗅觉加工的影响。
DOI：
10.1037/a0026466
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发表时间：
2012
影响因子：
1.9
通讯作者：
Turetsky,BruceI
中科院分区：
文献类型：
--
作者：
Kamath,Vidyulata;Moberg,PaulJ;Gur,RaquelE;Doty,RichardL;Turetsky,BruceI
儿茶酚-O-甲基转移酶（COMT）val 158 met多态性在精神分裂症中由于其在前额叶多巴胺catalysts中的作用而受到关注。鉴于嗅球丰富的多巴胺能神经支配和多巴胺对嗅觉信号传递的影响，作者研究了COMT基因型状态对精神分裂症患者嗅觉加工障碍的影响。宾夕法尼亚大学的精神分裂症患者（n= 42）和人口统计学匹配的健康对照组（n= 30）进行单鼻腔给药的识别测试。对个体进行COMT val 158 met多态性基因分型。观察到诊断和COMT基因型的统计学显著的相互作用，使得精神分裂症杂合子和Met纯合子相对于Val 158纯合子表现出受损的气味识别准确性。这些发现不能用抗精神病药物治疗状态、临床精神病学或人口统计学和疾病特征等因素来解释。值得注意的是，精神分裂症Val 158纯合子的气味识别性能与对照组相当。这些数据表明，在精神分裂症中观察到的气味识别障碍的COMT val 158 met多态性的影响。这种关系与初级嗅觉感觉传入的特定多巴胺能调节一致，而不是对认知过程的更广泛影响。未来的研究，检查嗅觉加工缺陷精神分裂症与其他嗅觉措施和COMT单倍型是必要的。（PsycINFO数据库记录（c）2018阿帕，保留所有权利）
The catechol-O-methyltransferase (COMT) val158met polymorphism has received attention in schizophrenia due to its role in prefrontal dopamine catabolism. Given the rich dopaminergic innervations of the olfactory bulb and the influence of dopamine on the transmission of olfactory signals, the authors examined the influence of COMT genotype status on the olfactory processing impairment observed in schizophrenia. The University of Pennsylvania Smell Identification Test was administered unirhinally to individuals with schizophrenia (n= 42) and a demographically matched sample of healthy controls (n= 30). Individuals were genotyped for the COMT val158met polymorphism. A statistically significant interaction of diagnosis and COMT genotype was observed, such that schizophrenia heterozygotes and Met homozygotes showed impaired odor identification accuracy relative to Val158 homozygotes. These findings could not be explained by factors such as antipsychotic medication status, clinical symptomatology, or demographic and illness characteristics. Notably, the schizophrenia Val158 homozygotes' odor identification performance was comparable to that of the control group. These data indicate that odor identification impairments observed in schizophrenia are influenced by the COMT val158met polymorphism. This relationship is consistent with specific dopaminergic modulation of primary olfactory sensory afferents, rather than a broader effect on cognitive processes. Future studies that examine the olfactory processing deficit in schizophrenia with respect to other olfactory measures and COMT haplotypes is warranted.(PsycINFO Database Record (c) 2018 APA, all rights reserved)