Internal Reflectivity of Filtering Blebs versus Intraocular Pressure in Patients with Recent Trabeculectomy
Internal Reflectivity of Filtering Blebs versus Intraocular Pressure in Patients with Recent Trabeculectomy
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DOI：
10.1167/iovs.10-5520
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发表时间：
2011-04-01
影响因子：
4.4
通讯作者：
Funk, Jens
中科院分区：
文献类型：
--
作者：
Pfenninger, Lukas;Schneider, Fabienne;Funk, Jens
目的.作者采用眼前节光学相干断层扫描（AS-OCT）对小梁切除术后不久的患者进行了滤过泡形态学分析，以寻找滤过泡成功或失败的进一步标准。使用AS-OCT对37名最近（< 2年）接受过小梁切除术的患者（43只眼）进行了1至4次测量。与超声生物显微镜相比，AS-OCT消除了与地球仪接触的水浴的需要。这是特别有价值的形态学参数的研究，可能会改变的接触和在术后期间，感染的关注是至关重要的。在这项研究中，滤过泡的液体填充腔的内部反射率与眼内压（IOP）进行了比较。患者的平均年龄为69.5岁（范围：27-84岁）。43只眼睛的平均术前IOP为20.6 mm Hg（范围：10-42 mm Hg），AS-OCT测量时的平均术后IOP为10.6 mm Hg（范围：2-40 mm Hg），平均IOP降低10.0 mm Hg（48.5%）。滤过泡囊腔内反射率与眼压呈良好的相关性（R-2 = 0.3762，n = 61，P < 0.0001）。AS-OCT是分析小梁切除术后滤过泡形态的有效工具。滤过泡充液腔的内部反射率与IOP之间存在高度显著相关性，这可能对评价滤过泡术后成功或失败具有未来影响。（Invest Ophthalmol维斯科学。2011; 52：2450-2455）DOI：10.1167/iovs.10-5520
PURPOSE. The authors conducted a morphology analysis of filtering blebs with anterior segment optical coherence tomography (AS-OCT) in patients shortly after trabeculectomy to find further criteria for success or failure of a filtering bleb.METHODS. Thirty-seven patients (43 eyes) who had recently (< 2 years) undergone trabeculectomy were measured 1 to 4 times with AS-OCT. In contrast to ultrasound biomicroscopy, AS-OCT eliminates the need for a water bath in contact with the globe. This is of particular value in a study of morphologic parameters that may be altered by contact and in the postoperative period when concerns of infection are paramount. In this study, the internal reflectivity of the fluid-filled cavity of the filtering bleb was compared with the intraocular pressure (IOP).RESULTS. Mean age of the patients was 69.5 years (range, 27-84 years). Average preoperative IOP of the 43 eyes was 20.6 mm Hg (range, 10-42 mm Hg), average postoperative IOP at the time of AS-OCT measurement was 10.6 mm Hg (range, 2-40 mm Hg), and mean IOP reduction was 10.0 mm Hg (48.5%). Internal reflectivity of the fluid-filled cavity of the filtering bleb correlated very well to the IOP (R-2 = 0.3762, n = 61, P < 0.0001).CONCLUSIONS. AS-OCT is a promising tool with which to analyze the morphology of the filtering bleb after trabeculectomy. A highly significant correlation between the internal reflectivity of the fluid-filled cavity of the filtering bleb and the IOP could be shown that may have future impact in evaluating the postoperative success or failure of filtering blebs. (Invest Ophthalmol Vis Sci. 2011; 52: 2450-2455) DOI: 10.1167/iovs.10-5520