The association between rest-activity parameters and hemoglobin A1c in patients with prediabetes.
The association between rest-activity parameters and hemoglobin A1c in patients with prediabetes.
复制标题
糖尿病前期患者的休息活动参数与糖化血红蛋白之间的关联。
DOI：
10.1080/07420528.2023.2215337
复制
发表时间：
2023
影响因子：
2.8
通讯作者：
Reutrakul,Sirimon
中科院分区：
文献类型：
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作者：
Paewponsong,Jirayupa;Gerber,BenS;Anothaisintawee,Thunyarat;Chirakalwasan,Naricha;Saetung,Sunee;Reutrakul,Sirimon
昼夜节律异常会对葡萄糖代谢产生不利影响。这项研究确定了行为昼夜节律参数，通过静息-活动节律评估，是否是糖尿病前期患者血糖控制的预测因子。79例糖尿病前期患者参加了研究。非参数静息-活动节律参数、睡眠持续时间和效率从7-d活动记录仪记录中获得。使用家庭睡眠呼吸暂停测试评估睡眠呼吸障碍的严重程度。获得血红蛋白A1 c（HbA 1c）以评价血糖控制。结果显示，较短的睡眠时间，较低的相对振幅和较高的L5（最不活跃的5小时期间的平均活动）与较高的HbA 1c相关，而其他睡眠变量与HbA 1c无关。校正年龄、性别、体重指数和睡眠时间后的多元逐步回归分析显示，较低的相对振幅（而非L5）与较高的HbA 1c独立相关（B =-0.027，p = 0.031）。总之，在糖尿病前期患者中，昼夜节律异常与较高的HbA 1c相关，这意味着发生糖尿病的风险更大。这些结果支持昼夜节律在糖尿病前期血糖控制中的作用。
Circadian abnormalities can adversely affect glucose metabolism. This study determined whether behavioral circadian parameters, as assessed by rest–activity rhythm, were predictors of glycemic control in patients with prediabetes. Seventy-nine patients with prediabetes participated. Nonparametric rest–activity rhythm parameters, sleep duration and efficiency were obtained from 7-d actigraphy recordings. Sleep-disordered breathing severity was assessed using a home sleep apnea test. Hemoglobin A1c (HbA1c) was obtained to evaluate glycemic control. The results revealed that shorter sleep duration, lower relative amplitude and higher L5 (average activity of the least active 5-h period) were associated with higher HbA1c, while other sleep variables were not related to HbA1c. Multiple stepwise regression analysis adjusting for age, sex, body mass index and sleep duration revealed that lower relative amplitude, but not L5, was independently associated with higher HbA1c (B = −0.027,p= 0.031). In summary, among patients with prediabetes, an abnormal circadian rhythm was associated with higher HbA1c, implying a greater risk of developing diabetes. These results support the role of circadian rhythmicity in glucose control among those with prediabetes.