5-HT Receptors and Temperature Homeostasis.
5-HT Receptors and Temperature Homeostasis.
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DOI：
10.3390/biom11121914
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发表时间：
2021-12-20
期刊：
影响因子：
5.5
通讯作者：
Voronova IP
中科院分区：
文献类型：
--
作者：
Voronova IP
本文综述了5-羟色胺（5-HT）受体对温血动物体温及其维持过程的影响。本文综述了从最初的研究到最新的研究的最重要的部分。讨论了5-HT1A、5-HT3、5-HT7和5-HT2受体类型药理激活的已有结果。前3种受体的激活导致体温下降，而5-HT2的激活导致体温升高。本文讨论了5-羟色胺受体激活引起体温变化的生理机制。在5-HT1A受体的情况下，它们包括抑制寒战和非寒战产热，以及同时增加外周血流量，即热产生和热损失的过程。5-HT2受体介导的生理过程与5-HT1A受体的生理过程相反。5-HT3和5-HT7受体参与这些过程的机制尚未得到更详细的研究。一些事实表明，在自然条件下，没有药理作用，这些5-HT受体是温度稳态系统的重要环节，也进行了讨论。
The present review summarizes the data concerning the influence of serotonin (5-HT) receptors on body temperature in warm-blooded animals and on processes associated with its maintenance. This review includes the most important part of investigations from the first studies to the latest ones. The established results on the pharmacological activation of 5-HT1A, 5-HT3, 5-HT7 and 5-HT2 receptor types are discussed. Such activation of the first 3 type of receptors causes a decrease in body temperature, whereas the 5-HT2 activation causes its increase. Physiological mechanisms leading to changes in body temperature as a result of 5-HT receptors’ activation are discussed. In case of 5-HT1A receptor, they include an inhibition of shivering and non-shivering thermogenesis, as well simultaneous increase of peripheral blood flow, i.e., the processes of heat production and heat loss. The physiological processes mediated by 5-HT2 receptor are opposite to those of the 5-HT1A receptor. Mechanisms of 5-HT3 and 5-HT7 receptor participation in these processes are yet to be studied in more detail. Some facts indicating that in natural conditions, without pharmacological impact, these 5-HT receptors are important links in the system of temperature homeostasis, are also discussed.
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影响因子：
5.5
作者：
BLIGH, J;COTTLE, WH;MASKREY, M
通讯作者：
MASKREY, M
影响因子：
7.3
作者：
BERENDSEN, HHG;BROEKKAMP, CLE
通讯作者：
BROEKKAMP, CLE
5-HT3受体 - 结构与功能之间的关系。
影响因子：
4.7
作者：
Barnes NM;Hales TG;Lummis SC;Peters JA
通讯作者：
Peters JA
影响因子：
4.1
作者：
Buchborn, Tobias;Lyons, Taylor;Knopfel, Thomas
通讯作者：
Knopfel, Thomas
DOI：
10.1016/j.bbamcr.2016.04.013
发表时间：
2016-10-01
影响因子：
5.1
作者：
Bouillaud, Frederic;Alves-Guerra, Marie-Clotilde;Ricquier, Daniel
通讯作者：
Ricquier, Daniel