Interleukin-10 genotypes are associated with systemic sclerosis and influence disease-associated autoimmune responses
Interleukin-10 genotypes are associated with systemic sclerosis and influence disease-associated autoimmune responses
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DOI：
10.1038/sj.gene.6364180
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发表时间：
2005-05-01
影响因子：
5
通讯作者：
Pandey, JP
中科院分区：
文献类型：
--
作者：
Hudson, LL;Rocca, KM;Pandey, JP
系统性硬化症（SSc;硬皮病）是一种结缔组织疾病，以纤维化、免疫学和血管异常为特征。白细胞介素-10（IL-10）是一种抗炎细胞因子，其调节胶原蛋白产生和B细胞存活。为了确定某些IL-10基因型是否是SSc发展的危险因素并影响疾病相关的自身免疫反应，对248名高加索人和264名日本SSc患者和对照进行了三个位点的基因分型：-3575，-2849和-2763。患者血清的特征在于Ssc相关的自身抗体。在白种人中，在-3575和-2763处，患者中AA纯合子的频率高于对照组（P = 0.0005; P = 0.002）。在日本受试者中，与对照组相比，弥漫性SSc患者-2763位点AC杂合子的频率较高，CC纯合子的频率较低（P = 0.04）。特定的IL-10基因型与SSC相关的自身抗体相关。这些结果表明，IL-10基因型有助于硬皮病的病因。
Systemic sclerosis (SSc; scleroderma) is a connective tissue disease, characterized by fibrotic, immunological, and vascular abnormalities. Interleukin-10 (IL-10) is an anti-inflammatory cytokine that modulates collagen production and B-cell survival. To determine if certain IL-10 genotypes are risk factors for the development of SSc and influence disease-associated autoimmune responses, 248 Caucasian and 264 Japanese SSc patients and controls were genotyped for three loci: - 3575, - 2849, and - 2763. Sera from patients were characterized for SSc-associated autoantibodies. In Caucasians, at - 3575 and - 2763, the frequency of AA homozygotes was higher in patients as compared with controls ( P = 0.0005; P = 0.002). In Japanese subjects, the frequency of AC heterozygotes at - 2763 was higher, and that of CC homozygotes lower, in patients with diffuse SSc as compared to controls ( P = 0.04). Particular IL-10 genotypes were associated with SSc-related autoantibodies. These results suggest that IL-10 genotypes contribute to the etiology of scleroderma.