The Interplay of Coronary Vascular Resistance and Myocardial Compression in Regulating Coronary Flow
The Interplay of Coronary Vascular Resistance and Myocardial Compression in Regulating Coronary Flow
复制标题
冠状动脉血管阻力和心肌压缩在调节冠状动脉血流中的相互作用
作者：
C. Wiggers
通过整合相位冠状窦血流曲线，可以比较收缩期加等长收缩期的体积流量和舒张期剩余时间的体积流量，可以评估心室压缩和冠状动脉阻力对平均冠状动脉流量的相对贡献。研究发现，缺氧、腺苷酸、主动脉或肺动脉受压可降低冠状动脉血管阻力，而肾上腺素可增加冠状动脉血管阻力，肾上腺素引起的冠状动脉平均流量增加完全是由于心室收缩力增大所致。根据这些证据，建议以修改后的形式复兴“按摩理论”。偶然获得的证据支持了先前的结论，即冠状窦引流由右冠状动脉和左冠状动脉供血的区域。
By integrating phasic coronary sinus flow curves in such a way that volume flow during systole plus isometric contraction and that during the remainder of diastole can be compared, the relative contribution of ventricular compression and coronary resistance to mean coronary flow can be assessed. It was found that anoxia, adenylic acid, compression of the aorta or pulmonary artery reduces coronary vascular resistance while epinephrine increases it. The augmentation in coronary mean flow following epinephrine is due solely to the greater force of ventricular contractions. On the basis of such evidence a revival of the “massaging theory” in modified form is suggested. Evidence was incidentally obtained which supports a former conclusion that the coronary sinus drains territories supplied by the right as well as the left coronary artery.