Shape effects of filaments versus spherical particles in flow and drug delivery
Shape effects of filaments versus spherical particles in flow and drug delivery
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DOI：
10.1038/nnano.2007.70
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发表时间：
2007-04-01
影响因子：
38.3
通讯作者：
Discher, Dennis E.
中科院分区：
文献类型：
--
作者：
Geng, Yan;Dalhaimer, Paul;Discher, Dennis E.
球形颗粒与细胞和动物体内的相互作用已经得到了广泛的研究，但形状的影响却很少受到关注。在这里，我们使用称为细丝胶束的高度稳定的聚合物胶束组件来比较柔性细丝与类似化学物质的球体的运输和运输。在啮齿类动物中，静脉注射后丝状胶束在循环中持续一周。这比球形纳米粒子长约十倍，比任何已知的合成纳米粒子都更持久。在流体流动条件下，球体和短丝胶束比长丝更容易被细胞吸收，因为后者会因流动而伸展。初步结果进一步证明，丝状胶束可以有效地传递抗癌药物紫杉醇，并缩小小鼠体内的人源性肿瘤。虽然这些发现表明，长期循环的载体不一定是纳米球，但它们也有助于洞察天然丝状病毒可能产生的形状效应。
Interaction of spherical particles with cells and within animals has been studied extensively, but the effects of shape have received little attention. Here we use highly stable, polymer micelle assemblies known as filomicelles to compare the transport and trafficking of flexible filaments with spheres of similar chemistry. In rodents, filomicelles persisted in the circulation up to one week after intravenous injection. This is about ten times longer than their spherical counterparts and is more persistent than any known synthetic nanoparticle. Under fluid flow conditions, spheres and short filomicelles are taken up by cells more readily than longer filaments because the latter are extended by the flow. Preliminary results further demonstrate that filomicelles can effectively deliver the anticancer drug paclitaxel and shrink human-derived tumours in mice. Although these findings show that long-circulating vehicles need not be nanospheres, they also lend insight into possible shape effects of natural filamentous viruses.