Thulium fiber laser lithotripsy:: An in vitro analysis of stone fragmentation using a modulated 110-watt thulium fiber laser at 1.94 μm
Thulium fiber laser lithotripsy:: An in vitro analysis of stone fragmentation using a modulated 110-watt thulium fiber laser at 1.94 μm
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DOI：
10.1002/lsm.20196
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发表时间：
2005-07-01
影响因子：
2.4
通讯作者：
Fried, NM
中科院分区：
文献类型：
--
作者：
Fried, NM
背景和目的：高功率铥光纤激光器已被证明可以快速汽化和凝固泌尿软组织（如前列腺）。这是高功率铥光纤激光器用于尿路结石碎裂的首次初步研究。研究设计/材料与方法：将工作波长为1.94 pm的连续波高功率铥光纤激光器调制为脉冲模式，输出脉冲能量为1J，通过300 μ m芯石英光纤，脉冲长度为20毫秒，重复频率为10 Hz。测定尿酸（UA） （n = 13）和一水草酸钙（COM） （n - 6）结石破碎时间，使其还原为< 2mm的颗粒。结果：UA和COM结石的平均初始质量分别为860 +/- 211和763 +/- 204 mg。碎裂率分别为388 +/- 49和25 +/- 2 mg/min。将UA和COM结石破碎成< 2 mm颗粒的平均时间分别为2.25 +/- 0.63和30.7 +/- 8.4分钟。结论：高功率铥光纤激光器在脉冲模式下均能粉碎软（UA）和硬（COM）型尿路结石。铥光纤激光器可作为一个单一的激光系统用于泌尿外科的多个软硬组织激光消融应用。
Background and Objectives: The high-power Thulium fiber laser has previously been shown to rapidly vaporize and coagulate soft urinary tissues (e.g., prostate). This is the first preliminary study of a high-power Thulium fiber laser for fragmentation of urinary stones.Study Design/Materials and Methods: A continuous-wave, high-power Thulium fiber laser operating at a wavelength of 1.94 pm, was modulated to operate in pulsed mode with an output pulse energy of 1J through a 300-mu m-core silica fiber at a 20 milliseconds pulse length and repetition rate of 10 Hz. The fragmentation time to reduce uric acid (UA) (n = 13) and calcium oxalate monohydrate (COM) (n - 6) stones into particles < 2 mm was measured.Results: Mean initial mass of the UA and COM stones measured 860 +/- 211 and 763 +/- 204 mg. Fragmentation rates measured 388 +/- 49 and 25 +/- 2 mg/minute. Average time needed to fragment the UA and COM stones into particles < 2 mm was 2.25 +/- 0.63 and 30.7 +/- 8.4 minutes, respectively.Conclusions: The high-power Thulium fiber laser, when operated in pulsed mode, is capable of fragmenting both soft (UA) and hard (COM) urinary stones. The Thulium fiber laser may be useful as a single laser system for use in multiple soft and hard tissue laser ablation applications in urology.