Middle- and high-molecular weight adiponectin levels in relation to nonalcoholic fatty liver disease
Middle- and high-molecular weight adiponectin levels in relation to nonalcoholic fatty liver disease
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中分子量和高分子量脂联素水平与非酒精性脂肪肝的关系
DOI：
10.1002/jcla.23148
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发表时间：
2019-12-27
影响因子：
2.7
通讯作者：
Wang, Qin
中科院分区：
文献类型：
--
作者：
Lian, Kun;Feng, Yu-Nan;Wang, Qin
目的脂联素（APN）以高分子量（HMW）、中分子量（MMW）和低分子量（LMW）三种形式存在。非酒精性脂肪肝（NAFLD）是慢性肝病的常见原因。目前，LMW、MMW和HMW APN在NAFLD中的作用在很大程度上仍不清楚。方法观察NAFLD患者上述形态的变化，并分析其相关临床特点。共有63名男性NAFLD患者（平均年龄：43.00 +/- 6.10岁）和70名健康男性受试者（平均年龄：42.53 +/- 7.98岁）被纳入研究。测量总APN和其他临床特征。在NAFLD患者和高脂饮食的NAFLD患者中测定HMW、MMW和LMW APN的变化，并进一步分析各组之间的相关性。结果NAFLD患者血清总APN及APN 3种亚型水平均降低。高脂饮食患者的HMW（P <0.01）和MMW（P <0.001）水平在NAFLD中显著降低。在NAFLD患者中，身高（R =-0.270，P = 0.032）和N-羧甲基赖氨酸（R =-0.259，P = 0.040）与总APN显著相关。HMW APN与空腹血糖（R = 0.350，P = 0.016）、丙氨酸氨基转移酶（R =-0.321，P = 0.029）和天冬氨酸氨基转移酶（R =-0.295，P = 0.045）显著相关。此外，MMW APN与总胆固醇（R = 0.357，P = 0.014）和高密度脂蛋白（R = 0.556，P <0.0001）显著相关。低密度脂蛋白（R =-0.283，P = 0.054）也与NAFLD患者的LMW APN明显相关。结论HMW和MMW APN可能参与了NAFLD的发生和发展。
Objective Adiponectin (APN) circulates as high-molecular weight (HMW), medium-molecular weight (MMW), and low-molecular weight (LMW) forms. Nonalcoholic fatty liver disease (NAFLD) is a common cause of chronic liver disease. Currently, the role of LMW, MMW, and HMW APN remains largely unclear in NAFLD. Methods We examined the variation of these forms and analyzed the related clinical characteristics in NAFLD. A total of 63 male NAFLD patients (mean age: 43.00 +/- 6.10 years) and 70 healthy male subjects (mean age: 42.53 +/- 7.98 years) were included in the study. Total APN and other clinical characteristics were measured. The changes in HMW, MMW, and LMW APN were determined in NAFLD patients and NAFLD patients on a high-fat diet, and the association between the groups was further analyzed. Results Decreased levels of total APN and three APN isoforms were found in NAFLD. Significantly decreased levels of HMW (P < .01) and MMW (P < .001) were observed in NAFLD of high-fat diet patients. In NAFLD patients, height (R = -.270, P = .032) and N-epsilon-(carboxymethyl) lysine (R = -.259, P = .040) significantly correlated with total APN. HMW APN was significantly associated with fasting plasma glucose (R = .350, P = .016), alanine aminotransferase (R = -.321, P = .029), and aspartate aminotransferase (R = -.295, P = .045). Additionally, MMW APN was significantly associated with total cholesterol (R = .357, P = .014) and high-density lipoprotein (R = .556, P < .0001). Low-density lipoprotein (R = -.283, P = .054) was also clearly associated with LMW APN in NAFLD patients. Conclusion These results suggest that HMW and MMW APN may be involved in the pathogenesis and progression of NAFLD.