International Immunonutrition Workshop Session 8 : Probiotics in the defence and metabolic balance of the organism Probiotics and the immune response to vaccines
International Immunonutrition Workshop Session 8 : Probiotics in the defence and metabolic balance of the organism Probiotics and the immune response to vaccines
复制标题
国际免疫营养研讨会第八场：益生菌在机体防御和代谢平衡中的作用益生菌与疫苗的免疫反应
DOI：
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发表时间：
2010
期刊：
影响因子：
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通讯作者：
Iona Bell
中科院分区：
文献类型：
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作者：
T. Macdonald;Iona Bell
益生菌是细菌，但有时是真菌，通过口服途径服用可能会给健康带来一些好处。益生菌有益作用的最令人信服的证据是预防和减少与肠道传染病相关的症状的持续时间。还有证据表明，某些特定的益生菌对老年人艰难梭菌腹泻有益。随着进一步和更好的对照临床研究的出现，一些特定的益生菌似乎也具有有益的作用，可能可以预防和减少获得性上呼吸道感染引起的症状持续时间。为了解释这些影响，人们的注意力转向了某些特定益生菌对免疫系统的影响。有证据表明，某些特定的益生菌可以改变血液中的单核细胞和自然杀伤细胞的功能。越来越多的证据表明，服用一些特定的益生菌可以增强对口服和全身注射疫苗的抗体反应。所显示的效果是适度的，并且并不总是在针对所有疫苗的不同研究中看到，但有足够的趋势使该领域值得进一步研究，特别是梳理所涉及的机制。
Probiotics are bacteria, but sometimes fungi, which when taken by the oral route may give some health benefits. The most compelling evidence for beneficial effects of probiotics is in the prevention and reduction in the duration of symptoms related to gut infectious disease. There is also evidence to show that some specific probiotics are beneficial in Clostridium difficile diarrhoea in the elderly. As further and better controlled clinical studies have appeared, some specific probiotics also appear to have beneficial effects in perhaps preventing and reducing the duration of symptoms due to acquired upper respiratory tract infections. In an attempt to explain these effects, attention has turned to the effects of some specific probiotics on the immune system. There is evidence that some specific probiotics can alter monocyte and natural killer cell function in the blood. Evidence is also accumulating that taking some specific probiotics can boost antibody responses to oral and systemically administered vaccines. The effect when shown is modest and is not always seen in different studies to all vaccines, but there is enough of a trend to make the area worthy of further investigation, particularly to tease out the mechanisms involved.
DOI：
10.1073/pnas.0500098102
发表时间：
2005-02-22
影响因子：
11.1
作者：
Mohamadzadeh, M;Olson, S;Klaenhammer, TR
通讯作者：
Klaenhammer, TR