A semi-empirical treatment planning model for optimization of multiprobe cryosurgery
A semi-empirical treatment planning model for optimization of multiprobe cryosurgery
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DOI：
10.1088/0031-9155/45/5/301
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发表时间：
2000-05-01
影响因子：
3.5
通讯作者：
Rewcastle, JC
中科院分区：
文献类型：
--
作者：
Baissalov, R;Sandison, GA;Rewcastle, JC
提出了一种多探头冷冻外科治疗计划的模型。在该模型中，热模拟算法用于从冷冻探针生成温度分布，可视化感兴趣的解剖区域（ROI）中的等温线，并提供工具以帮助估计对目标和周围正常结构的冷冻损伤量。对于所选择的一组操作参数，可以针对任何给定的冻结时间执行计算。热模拟是基于使用有限元法求解瞬态热传导方程的多探头几何形状。作为一个例子，一个半经验优化的二维放置的六个冷冻探针和他们的热协议的第一个冷冻周期。通过生成温度-体积直方图并计算目标函数来评估优化治疗方案的有效性。进行了两次体模实验，以验证通过计算预测的等温线位置。预测的0摄氏度等温线与通过X射线CT成像的实际冰球边界的比较证明了+/-2 mm内的空间一致性。
A model is presented for treatment planning of multiprobe cryosurgery. In this model a thermal simulation algorithm is used to generate temperature distribution from cryoprobes, visualize isotherms in the anatomical region of interest (ROI) and provide tools to assist estimation of the amount of freezing damage to the target and surrounding normal structures. Calculations may be performed for any given freezing time for the selected set of operation parameters. The thermal simulation is based on solving the transient heat conduction equation using finite element methods for a multiprobe geometry. As an example, a semi-empirical optimization of 2D placement of six cryoprobes and their thermal protocol for the first freeze cycle is presented. The effectiveness of the optimized treatment protocol was estimated by generating temperature-volume histograms and calculating the objective function for the anatomy of interest. Two phantom experiments were performed to verify isotherm locations predicted by calculations. A comparison of the predicted 0 degrees C isotherm with the actual iceball boundary imaged by x-ray CT demonstrated a spatial agreement within +/-2 mm.