CD44: More than a mere stem cell marker
CD44: More than a mere stem cell marker
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DOI：
10.1016/j.biocel.2016.09.009
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发表时间：
2016-12-01
影响因子：
4
通讯作者：
Orian-Rousseau, V.
中科院分区：
文献类型：
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作者：
Morath, I.;Hartmann, T. N.;Orian-Rousseau, V.
CD44是一种细胞粘附分子，在肿瘤的进展和转移中起重要作用。CD44在肿瘤发生中的作用是由于它与细胞外基质成分结合，包括透明质酸（HA）和骨桥蛋白（OPN），以及与信使分子结合，如肿瘤微环境中的生长因子。HA和OPN在白血病干细胞生态位和各种癌症类型的实体肿瘤中高度丰富，它们有助于维持恶性细胞的干性。因此，CD44已被认为是几种类型癌症的癌症干细胞标记物，这已成为最近许多研究的主题。在这篇综述中，我们讨论了CD44如何通过与细胞外基质成分、生长因子和细胞因子的相互作用来促进癌细胞的生长。(C) 2016 Elsevier Ltd.版权所有。
CD44 is a cell adhesion molecule that plays an important role in tumor progression and metastasis. The role of CD44 in tumorigenesis is due to its binding to extracellular matrix components, including hyaluronan (HA) and osteopontin (OPN), and to messenger molecules, such as growth factors present in the tumor microenvironment. HA and OPN are highly abundant in the leukemic stem cell niche and in solid tumors of various cancer types, where they contribute to the maintenance of the stemness of malignant cells. CD44 has consequently been recognized as a cancer stem cell marker in several types of cancers, which has been a topic of much recent research. In this review we have addressed the question of how CD44 might promote cancer cell sternness by interacting with extracellular matrix components, growth factors and cytokines. (C) 2016 Elsevier Ltd. All rights reserved.