Cholesterol Metabolism in Gonadectomized Rats
Cholesterol Metabolism in Gonadectomized Rats
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性腺切除大鼠的胆固醇代谢
DOI：
10.1161/01.res.6.2.172
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发表时间：
1958
影响因子：
20.1
通讯作者：
R. Alfin
中科院分区：
文献类型：
--
作者：
R. D. Coleman;Y. Chen;R. Alfin
在测定喂食含脂肪对照饲料的雄性和雌性大鼠的胆固醇和总脂质组织浓度的研究中，性腺切除术的影响远小于喂食无脂肪饲料的动物，而在无脂肪饲料中，性腺切除术往往会逆转在这些脂质值中观察到的性别差异。脂质代谢的其他阶段也显示出与性别相关。性腺切除导致大鼠肝片中胆固醇合成减少，肝脏中胆固醇酯的脂肪酸组成发生变化。
In studies in which tissue concentrations of cholesterol and total lipids were determined in male and female rats fed a control diet containing fat, the effects of gonadectomy were much smaller than in animals fed a fat-free diet in which gonadectomy tended to reverse the sex differences observed in these lipid values. Other phases of lipid metabolism were shown to be sex-linked as well. Gonadectomy resulted in decreased synthesis of cholesterol in rat liver slices and changes in the fatty acid composition of cholesterol esters in the liver.