Tumor-targeted delivery of siRNA by non-viral vector: safe and effective cancer therapy.
Tumor-targeted delivery of siRNA by non-viral vector: safe and effective cancer therapy.
复制标题
DOI：
10.1517/17425240802568505
复制
发表时间：
2008-12
影响因子：
6.6
通讯作者：
Huang L
中科院分区：
文献类型：
--
作者：
Chen Y;Huang L
RNA干扰技术已经发展成为一种潜在的治疗药物，用于许多适应症，包括癌症。在体外和体内，沉默肿瘤细胞中的特定癌基因会导致细胞死亡。然而，为了提高小干扰RNA （small interfering RNA, siRNA）的治疗效果，迫切需要强有力的递送策略。本文综述了siRNA抑制的不同信号通路以及靶向siRNA作为递送系统的优势。
RNA interference technology has been developed as a potential therapeutic agent for many indications, including cancer. Silencing a specific oncogene in tumor cells brings about cell death both in vitro and in vivo. However, there is a great need for powerful delivery strategies to enhance the therapeutic effect of small interfering RNA (siRNA). This review summarizes different signaling pathways inhibited by siRNA and the advantages of targeted siRNA as a delivery system.