Phenylpropanoids and neolignans from Smilax trinervula
Phenylpropanoids and neolignans from Smilax trinervula
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来自三脉菝葜的苯丙素和新木脂素
DOI：
10.1016/j.fitote.2015.05.010
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发表时间：
2015-07-01
期刊：
影响因子：
3.4
通讯作者：
Huang, Huilian
中科院分区：
文献类型：
--
作者：
Shu, Jicheng;Liang, Fang;Huang, Huilian
一种新的苯丙类糖苷和两种新的新木质素，即(1S, 2R)-1-（3,4,5 -三甲氧基苯基）-3-（β -d -葡萄糖吡喃氧基）- 1,2,3 -丙烯三醇(1)和(7R, 8R)- 4,7,9,9 '-四羟基- 3,5,3 ',5'-四甲基-8-4'-氧新木质素-4- o - β -d -葡萄糖吡喃苷(2)和3',9,9 '-三羟基- 3,5 -二甲氧基-8- o -4'-新木质素-4- o - β -d -葡萄糖吡喃苷(3)，以及一种新的天然产物(1S, 2R)-1-（3,4,5 -三甲氧基苯基）- 1,2。从菝葜根茎中分离得到3-丙三醇(4)和4个已知化合物（5-8）。它们的结构主要是基于一维和二维核磁共振波谱数据、ESI-MS和文献对比确定的。化合物1 ~ 8对5种人肿瘤细胞系SH-SY5Y、SGC-7901、HCT-116、Lovo和Vero的细胞毒活性进行了体外实验。化合物7和8对Lovo具有细胞毒活性，IC50值分别为18.7 μ M和16.8 μ M。(C) 2015 Elsevier B.V.版权所有
A new phenylpropanoid glucoside and two new neolignans, namely (1S, 2R)-1-(3, 4, 5-trimethoxyphenyl)-3-(beta-D-glucopyranosyloxy)-1, 2, 3-propanetriol (1), and (7R, 8R)-4, 7, 9, 9'-tetrahydroxy-3, 5,3', 5'-tetramethoxy-8-4'-oxyneolignan 4-O-beta-D-glucopyranoside (2) and 3', 9, 9'-trihydroxy-3, 5-dimethoxy-8-O-4'-neolignan-4-O-beta-D-glucopyranoside (3), together with a new natural product (1S, 2R)-1-(3, 4, 5-trimethoxyphenyl)-1, 2, 3-propanetriol (4) and four known compounds (5-8) were isolated from the rhizomes of Smilax trinervula. Their structures were established mainly on the basis of 1D and 2D NMR spectral data, ESI-MS and literature comparisons. Compounds 1-8 were tested in vitro for their cytotoxic activities against 5 human tumor cell lines (SH-SY5Y, SGC-7901, HCT-116, Lovo and Vero). Compounds 7 and 8 exhibited cytotoxic activity against Lovo, with IC50 values of 18.7 mu M and 16.8 mu M, respectively. (C) 2015 Elsevier B.V. All rights reserved.