Understanding Muscle Protein Dynamics: Technical Considerations for Advancing Sarcopenia Research.
Understanding Muscle Protein Dynamics: Technical Considerations for Advancing Sarcopenia Research.
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DOI：
10.4235/agmr.20.0041
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发表时间：
2020-09
影响因子：
3.6
通讯作者：
Wolfe RR
中科院分区：
文献类型：
--
作者：
Kim IY;Park S;Jang J;Wolfe RR
肌肉减少症是随着衰老发生的肌肉质量和力量的损失，涉及不平衡的肌肉蛋白质周转（即，蛋白质分解超过合成），这又加重了其它临床病症，例如2型糖尿病、肥胖症、骨质疏松症和癌症，从而恶化了老年人的生活质量。这种不平衡部分归因于老年肌肉对合成代谢刺激的抵抗，如膳食蛋白质/氨基酸和称为合成代谢抵抗的抵抗运动。尽管研究工作，没有实际的治疗方法已经成功地发现，可能是因为缺乏对肌肉蛋白质的动态性质的理解，以及使用肌肉质量的间接评估。在此，我们简要讨论了蛋白质周转率的调节，以响应上述合成代谢刺激的合成代谢阻力和最佳蛋白质摄入量，其次是推进肌肉减少症研究的方法学考虑，包括肌肉质量和动力学的评估。
Sarcopenia, which is the loss of muscle mass and strength that occurs with aging, involves imbalanced muscle protein turnover (i.e., protein breakdown exceeding synthesis), which in turn exacerbates other clinical conditions such as type 2 diabetes mellitus, obesity, osteoporosis, and cancer, thereby worsening the quality of life in older adults. This imbalance is attributed in part to the resistance of aged muscle to anabolic stimuli such as dietary protein/amino acids and resistance exercise known as anabolic resistance. Despite research efforts, no practical therapeutics have been successfully discovered possibly because of a lack of understanding of the dynamic nature of muscle protein, and the use of indirect assessments of muscle mass. Herein, we briefly discuss the regulation of protein turnover in response to the abovementioned anabolic stimuli with respect to anabolic resistance and optimal protein intake, followed by methodological considerations for advancing sarcopenia research, including assessments of muscle mass and dynamics.