Analysis of hedgehog interacting protein in the brain and its expression in nitric oxide synthase-positive cells
Analysis of hedgehog interacting protein in the brain and its expression in nitric oxide synthase-positive cells
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DOI：
10.1097/01.wnr.0000187632.91375.81
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发表时间：
2005-11-28
期刊：
影响因子：
1.7
通讯作者：
Traiffort, E
中科院分区：
文献类型：
--
作者：
Loulier, K;Ruat, M;Traiffort, E
Hedgehog相互作用蛋白（Hip）和Patched 1（Ptcl）调节细胞对形态原Sonic Hedgehog（Shh）的反应。在这里，我们比较了相对表达模式的Shh，髋关节和Ptcl转录E13.5小鼠脑胚胎。我们观察到，髋关节和Ptcl的表达往往重叠，并发现接近Shh表达细胞，这表明这两种蛋白质是控制Shh信号所必需的。在成年纹状体中，没有检测到Ptcl，我们表明，大多数的海马表达细胞对应于神经元表达的神经元形式的一氧化氮合酶。这些数据提出了一个假设，一氧化氮和Shh信号之间的功能联系，并为一个非冗余的作用，髋关节和Ptcl在成人大脑。
Hedgehog interacting protein (Hip) and Patched 1 (Ptcl) regulate the cell responses to the morphogen Sonic Hedgehog (Shh). Here, we compare the relative expression patterns of Shh, Hip and Ptcl transcripts in the E13.5 mouse brain embryo. We observe that the expression of Hip and Ptcl often overlaps and is found close to Shh-expressing cells, suggesting that both proteins are required for controlling Shh signals. In the adult striatum in which Ptcl is not detected, we show that a majority of Hip-expressing cells correspond to neurons expressing the neuronal form of nitric oxide synthase. These data raise the hypothesis for a functional link between nitric oxide and Shh signaling and for a nonredundant role of Hip and Ptcl in the adult brain.