Hybrid 2D nanomaterials as dual-mode contrast agents in cellular imaging.
Hybrid 2D nanomaterials as dual-mode contrast agents in cellular imaging.
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DOI：
10.1002/adma.201200706
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发表时间：
2012-06-12
影响因子：
29.4
通讯作者：
Ajayan, Pulickel M.
中科院分区：
文献类型：
--
作者：
Narayanan, Tharangattu N.;Gupta, Bipin K.;Vithayathil, Sajna A.;Aburto, Rebeca R.;Mani, Sendurai A.;Taha-Tijerina, Jaime;Xie, Bin;Kaipparettu, Benny A.;Torti, Suzy V.;Ajayan, Pulickel M.
多功能纳米流体的设计对于生物医学治疗/细胞成像应用是高度期望的。[1-4]具有特定性质（如磁性和荧光）的混合纳米材料的出现可以导致在生物分子水平上理解生物过程。[1]在最近的过去，已经分析了各种混合动力系统的几种可能的生物医学应用。[5-9]碳基混合系统，如碳纳米管与各种纳米粒子正在广泛测试其生物学应用，因为它们的能力，通过细胞膜和有趣的热和电性能。[10氧化石墨烯（GO）是一种相当新的基于石墨烯的系统，其具有用连接到主链的许多官能团装饰的2D碳蜂窝晶格：这些官能团使其成为用于进一步连接纳米颗粒和合成杂化材料的优异平台。最近尝试了GO的细胞活力研究，显示出生物相容性。[12此外，GO的固有光致发光（PL）性质可用于细胞成像。[13]大的比表面积和与芳香分子的非共价相互作用使GO成为生物分子应用和药物附着的优良体系。另一方面，自1957年磁性材料被提出用于热疗癌症以来，磁场辅助生物分子成像、药物递送和治疗在纳米生物技术中受到了极大的关注。[14]氧化铁（Fe 3 O 4）由于其相当大的饱和磁化强度（87 emu g-1）、令人感兴趣的输运性质以及最重要的高磁性，在各种磁性材料中占据独特的位置。
The design of multifunctional nanofluids is highly desirable for biomedical therapy/cellular imaging applications.[1–4] The emergence of hybrid nanomaterials with specific properties, such as magnetism and fluorescence, can lead to an understanding of biological processes at the biomolecular level.[1] Various hybrid systems have been analyzed in the recent past for several possible biomedical applications.[5–9] Carbon-based hybrid systems such as carbon nanotubes with various nanoparticles are being widely tested for their biological applications because of their ability to cross cell membranes and their interesting thermal and electrical properties.[10, 11] Graphene oxide (GO) is a fairly new graphene-based system with a 2D carbon honeycomb lattice decorated with numerous functional groups attached to the backbone: these functional groups make it an excellent platform for further attachment of nanoparticles and synthesis of hybrid materials. Cell viability studies on GO have been recently attempted, showing biocompatibility.[12, 13] Moreover, the intrinsic photoluminescence (PL) properties of GO can be utilized for cellular imaging.[13] The large surface area and non-covalent interactions with aromatic molecules make GO an excellent system for biomolecular applications and drug attachment.On the other hand, magnetic-field-assisted biomolecular imaging, drug delivery, and therapy have received tremendous attention in nano-biotechnology since the proposal of magnetic materials for hyperthermia treatment of cancer, in 1957.[14] Iron oxide (Fe3O4) occupies a unique position among the various magnetic materials as a result of its considerable saturation magnetization (87 emu g− 1), interesting transport properties, and, above all, high
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影响因子：
10.8
作者：
Richard, Cyrille;Doan, Bich-Thuy;Scherman, Daniel
通讯作者：
Scherman, Daniel
影响因子：
15.1
作者：
Kassaee, M. Z.;Motamedi, E.;Majdi, M.
通讯作者：
Majdi, M.
多功能纳米颗粒作为耦合对比剂。
影响因子：
16.6
作者：
Jin, Yongdong;Jia, Congxian;Huang, Sheng-Wen;O'Donnell, Matthew;Gao, Xiaohu
通讯作者：
Gao, Xiaohu
影响因子：
10.8
作者：
Hoare T;Santamaria J;Goya GF;Irusta S;Lin D;Lau S;Padera R;Langer R;Kohane DS
通讯作者：
Kohane DS
影响因子：
3.7
作者：
Mahmoudi, Morteza;Simchi, Abdolreza;Haefeli, Urs O.
通讯作者：
Haefeli, Urs O.