Inhibition of dopamine release by methylenedioxymethamphetamine is mediated by serotonin.
Inhibition of dopamine release by methylenedioxymethamphetamine is mediated by serotonin.
复制标题
亚甲二氧基甲基苯丙胺对多巴胺释放的抑制是由血清素介导的。
DOI：
10.1016/0014-2999(89)90567-0
复制
发表时间：
1989
影响因子：
5
通讯作者：
Howard,SG
中科院分区：
文献类型：
--
作者：
Gazzara,RA;Takeda,H;Cho,AK;Howard,SG
(±)-3,4-Methylenedioxymethamphetamine (MDMA), at doses of 0.1, 1 and 10 mg/kg, produced a long-lasting decrease in extracellular dopamine concentration in the neostriatum of anesthetized rats, as measured by in vivo voltammetry. Since MDMA has been shown to release serotonin from rat brain slices and synaptosomes, we examined the possibility that increased serotonin release might be the cause of the decrease in dopamine release. Rats were treated with d,l-p-chloroamphetamine seven days prior to acute MDMA administration. Rats pretreated with p-chloroamphetamine, which produced a marked decrease in serotonin content, showed no significant decrease in extracellular dopamine concentration when administered 10 mg/kg MDMA. These data suggest that MDMA produces a significant decrease in dopamine release when administered acutely, and that this decrease is an indirect effect mediated by an increase in serotonin release.
