Emerging roles for the BAI1 protein family in the regulation of phagocytosis, synaptogenesis, neurovasculature, and tumor development.
Emerging roles for the BAI1 protein family in the regulation of phagocytosis, synaptogenesis, neurovasculature, and tumor development.
复制标题
DOI：
10.1007/s00109-011-0759-x
复制
发表时间：
2011-08
影响因子：
4.7
通讯作者：
Van Meir, Erwin G.
中科院分区：
文献类型：
--
作者：
Cork, Sarah M.;Van Meir, Erwin G.
While G-protein-coupled receptors (GPCRs) have received considerable attention for their biological activity in a diversity of physiological functions and have become targets for therapeutic intervention in many diseases, the function of the cell adhesion subfamily of GPCRs remains poorly understood. Within this group, the family of brain angiogenesis inhibitor molecules (BAI1-3) has become increasingly appreciated for their diverse roles in biology and disease. In particular, recent findings suggest emerging roles for BAI1 in the regulation of phenomena including phagocytosis, synaptogenesis, and the inhibition of tumor growth and angiogenesis via the processing of its extracellular domain into secreted vasculostatins. Here we summarize the known biological features of the BAI proteins, including their structure, proteolysis events, and interacting partners, and their recently identified ability to regulate certain signaling pathways. Finally, we discuss the potential of the BAIs as therapeutics or targets for diseases as varied as cancer, stroke, and schizophrenia.
登录
查看更多内容
影响因子：
6.6
作者：
DeRosse P;Lencz T;Burdick KE;Siris SG;Kane JM;Malhotra AK
通讯作者：
Malhotra AK
影响因子：
4.3
作者：
Huang, Yue;Fan, Jun;Zhu, Guo-Zhang
通讯作者：
Zhu, Guo-Zhang
影响因子：
3.5
作者：
Jin, Zhaohui;Tietjen, Ian;Piao, Xianhua
通讯作者：
Piao, Xianhua
DOI：
10.1073/pnas.1019577108
发表时间：
2011-02-08
影响因子：
11.1
作者：
Bolliger, Marc F.;Martinelli, David C.;Suedhof, Thomas C.
通讯作者：
Suedhof, Thomas C.
影响因子：
11.2
作者：
Kaur B;Cork SM;Sandberg EM;Devi NS;Zhang Z;Klenotic PA;Febbraio M;Shim H;Mao H;Tucker-Burden C;Silverstein RL;Brat DJ;Olson JJ;Van Meir EG
通讯作者：
Van Meir EG