Increased content of zinc and iron in human cataractous lenses
Increased content of zinc and iron in human cataractous lenses
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DOI：
10.1385/bter:90:1-3:15
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发表时间：
2002-12-01
影响因子：
3.9
通讯作者：
Strobel, J
中科院分区：
文献类型：
--
作者：
Dawczynski, J;Blum, M;Strobel, J
本研究的目的是检测不同类型白内障患者晶状体中锌和铁的含量，并探讨糖尿病对晶状体锌和铁含量的可能影响。用原子吸收光谱法测定了57例人类晶状体(28例皮质核性白内障和29例成熟性白内障，平均年龄70.6±16.1岁和74.7±11.1岁，41例非糖尿病患者和16例糖尿病患者)的铁和锌。成熟性白内障晶状体锌含量显著高于皮质核性白内障(0.51+/-0.33vs0.32+/-0.20mumol/g干重，p=0.012)。成熟性白内障的铁含量也高于皮质核性白内障(0.11+/-0.09vs0.07+/-0.05mumol/g干重，p=0.071)。此外，随着晶状体颜色的增加，晶状体锌含量也显著增加(浅棕色0.33+/-0.17vs深棕色0.52+/-0.35mumol/g干重，p=0.032)。与非糖尿病患者相比，糖尿病患者晶状体中锌和铁的含量似乎都有所增加(锌：0.45+/-0.42比0.40+/-0.22摩尔/克干重；铁：0.12+/-0.10比0.08+/-0.05摩尔/克干重)。这些数据表明，晶状体中锌和铁的含量可能会影响晶状体混浊的发生。尤其是严重的白内障和深棕色的镜片显示锌和铁的含量显著增加。
The purpose of the study was to examine the zinc and iron content of human lenses in different types of cataract and to investigate the possible influence of diabetes on the zinc and iron content of the lens. Iron and zinc of 57 human lenses (28 corticonuclear cataracts and 29 mature cataracts with a mean age of 70.6 +/- 16.1 and 74.7 +/- 11.1 yr, 41 nondiabetics and 16 diabetics) were determined by atomic absorption spectroscopy. The zinc content of human lenses was significantly increased in mature cataracts compared to corticonuclear cataracts (0.51 +/- 0.33 vs 0.32 +/- 0.20 mumol/g dry mass, p=0.012). The iron content of mature cataracts was also higher than in corticonuclear cataracts (0.11 +/- 0.09 vs 0.07 +/- 0.05 mumol/g dry mass, p=0.071). Furthermore, a significant increase of the lens zinc content could be observed with increasing lens coloration (light brown 0.33 +/- 0.17 vs dark brown 0.52 +/- 0.35 mumol/g dry mass, p=0.032). Diabetic patients seem to have both increased zinc and iron contents in the lens compared to nondiabetic subjects (zinc: 0.45 +/- 0.42 vs 0.40 +/- 0.22 mumol/g dry mass; iron: 0.12 +/- 0.10 vs 0.08 +/- 0.05 mumol/g dry mass). These data suggest a possible influence of the lens zinc and iron content on the development of lens opacification. Especially advanced forms of cataract and dark brown colored lenses show significantly increased zinc and iron content.