Age-related changes in frontal and temporal lobe volumes in men - A magnetic resonance imaging study
Age-related changes in frontal and temporal lobe volumes in men - A magnetic resonance imaging study
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DOI：
10.1001/archpsyc.58.5.461
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发表时间：
2001-05-01
影响因子：
--
通讯作者：
Mintz, J
中科院分区：
文献类型：
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作者：
Bartzokis, G;Beckson, M;Mintz, J
背景：影像学和尸检研究提供了一致的证据，表明从青春期开始，灰质体积呈线性下降直至老年，而脑脊液体积在成年期（20 - 50岁）保持稳定。鉴于成年期颅骨体积固定，令人惊讶的是，大多数研究发现大约20岁以后白质体积没有增加。我们研究了衰老过程对额叶和颞叶的影响。
方法：70名年龄在19 - 76岁的健康成年男性接受了磁共振成像检查。使用能使灰质与白质对比度最大化的脉冲序列获取聚焦于额叶和颞叶的冠状图像。对额叶和颞叶的总体积以及灰质和白质亚成分的体积进行了评估。
结果：额叶灰质体积存在与年龄相关的线性减少（r = -0.62，P <...（此处原文似乎不完整）
Background? Imaging and postmortem studies provide converging evidence that, beginning in adolescence, gray matter volume declines linearly until old age, while cerebrospinal fluid volumes are stable in adulthood (age 20-50 years). Given the fixed volume of the cranium in adulthood, it is surprising that most studies observe no white matter volume expansion after approximately age 20 years. We examined the effects of the aging process on the frontal and temporal lobes.Methods: Seventy healthy adult men aged 19 to 76 years underwent magnetic resonance imaging. Coronal images focused on the frontal and temporal lobes were acquired using pulse sequences that maximized gray vs white matter contrast. The volumes of total frontal and temporal lobes as well as the gray and white matter subcomponents were evaluated.Results: Age-related linear loss in gray matter volume in both frontal(r=-0.62, P