Gonads directly regulate growth in teleosts
Gonads directly regulate growth in teleosts
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DOI：
10.1073/pnas.1118704109
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发表时间：
2012-07-10
影响因子：
11.1
通讯作者：
Miura, Takeshi
中科院分区：
文献类型：
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作者：
Bhatta, Sandip;Iwai, Toshiharu;Miura, Takeshi
一般来说，生长和繁殖之间存在关系，性腺被认为是生长的重要器官，但缺乏其作用的直接证据。在这里，我们使用鱼类模型报告了直接证据，证明性腺是内分泌器官，在控制身体生长方面与垂体同等。对罗非鱼的性腺功能丧失、功能获得和生长挽救进行了研究。在青少年男性和女性中进行了性腺切除实验。与对照组相比，性腺切除术显着延迟了生长；然而，这种迟缓可以通过植入摘除的性腺来挽救。由于性腺表达生长激素，因此性腺可能通过分泌生长激素和/或其他内分泌因子来控制身体生长。我们认为性腺是硬骨鱼生长动态调节中不可或缺的参与者。
In general, there is a relationship between growth and reproduction, and gonads are known to be important organs for growth, but direct evidence for their role is lacking. Here, using a fish model, we report direct evidence that gonads are endocrine organs equal to the pituitary in controlling body growth. Gonadal loss of function, gain of function, and rescue of growth were investigated in tilapia. Gonadectomy experiments were carried out in juvenile males and females. Gonadectomy significantly retarded growth compared with controls; however, this retardation was rescued by the implantation of extirpated gonads. Because gonads express growth hormone, it is possible that gonads control body growth through the secretion of growth hormone and/or other endocrine factors. We propose that gonads are integral players in the dynamic regulation of growth in teleosts.