Serum retinol and retinol-binding protein levels do not predict subsequent lung cancer.
Serum retinol and retinol-binding protein levels do not predict subsequent lung cancer.
复制标题
血清视黄醇和视黄醇结合蛋白水平不能预测随后的肺癌。
DOI：
10.1093/oxfordjournals.aje.a114307
复制
发表时间：
1986
影响因子：
5
通讯作者：
Orentreich,N
中科院分区：
文献类型：
--
作者：
Friedman,GD;Blaner,WS;Goodman,DS;Vogelman,JH;Brind,JL;Hoover,R;Fireman,BH;Orentreich,N
在对151名后来发现患有肺癌的人（病例）和302名没有患癌症的人（对照组）进行多阶段健康检查时，测量了先前获得并冷冻保存的血清中视黄醇和视黄醇结合蛋白的水平。每个病例在性别、肤色、年龄、多相健康检查日期和吸烟习惯方面都有两个对照。病例和对照组的平均水平分别为视黄醇：82.17和82.37 μg/dl (p=0.93)，视黄醇结合蛋白：6.04和6.00 μg/dl （p=0.81）。病例与对照组的平均差异为：视黄醇：0.195 μg/dl（95%置信限），−3.91和4.30 μg/dl；视黄醇结合蛋白：−0.033 μg/dl（95%置信限），−0.31和0.24 μg/dl。当视黄醇或视黄醇结合蛋白分布被分成五分位数时，没有观察到肺癌相对风险的显著趋势。在基于年龄、性别、癌症的组织学类型、吸烟或抽血与癌症诊断之间的间隔的亚组中没有观察到显著的关联。在这项大型研究中，视黄醇和视黄醇结合蛋白水平在预测肺癌的后续发展方面没有作用。
Retinol and retinol-binding protein levels were measured in sera previously obtained, and stored in the frozen state, at multiphasic health checkups from 151 persons subsequently found to have lung cancer (cases) and 302 persons who remained free of cancer (controls). Two controls were matched to each case for sex, skin color, age, date of multiphasic health checkup, and aspects of the smoking habit. Mean levels in cases and controls were, respectively, retinol: 82.17 and 82.37 μg/dl (p=0.93), and retinol-binding protein: 6.04 and 6.00 μg/dl (p=0.81). Mean differences between cases and controls were, retinol: 0.195 μg/dl with 95% confidence limits, −3.91 and 4.30 μg/dl; retinol-binding protein: −0.033 μg/dl with 95% confidence limits, −0.31 and 0.24 μg/dl. No significant trend in relative risk of lung cancer was observed when the retinol or retinol-binding protein distribution was divided into quintiles. No significant associations were observed in subgroups based on age, sex, histologic type of cancer, cigarette consumption, or interval between blood drawing and cancer diagnosis. In this large study, retinol and retinol-binding protein levels were not useful in predicting the subsequent development of lung cancer.